Enhanced Serum Cortisol Response to 5-Hydroxytryptophan in Depression and Mania

The serum cortisol responses in unmedicated depressed & manic patients are greater than those of normal controls. The levels of cortisol response correlate with symptoms of depression; thus, 5-HTP may be related to processes that lead to the intensification of depressive symptoms. Cortisol response to 5-HTP is greater in patients with first degree relatives with affective disorders. Cortisol response was also greater in those who attempted suicide. Some serotonin receptors may be responsible.