33 amoxapine overdoses, including 5 fatalities, were reported to 2 regional poison centres over an 18 month study period. The 15.2% mortality rate stands in alarming contrast to the 0.7% death rate for all other cyclic antidepressant overdoses reported to these same 2 centres during the study. Seizure activity was noted in 36.4% of amoxapine overdoses, compared with 4.3% of other cyclic antidepressant poisonings.