Year: 1982 Source: Science, v.216, no.4552, (June 1982), p.1337-1339 SIEC No: 19840407

Binding characteristics of tritiated imipramine were determined in the frontal cortex of 9 suicides (13-58 yr olds) & 9 controls (21-47). Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.