Year: 1977 Source: American Journal of Psychiatry, v.134, no.1, (January 1977), p.66-68 SIEC No: 19840221

Although a 1-week supply of tricyclic antidepressants is generally considered safe, the author shows that this amount can be severely toxic. Six of 12 instances of low-dose (500-1000 mg) amitriptyline overdoses were life threatening. The author suggests that prescription guidelines for tricyclic antidepressants be tightened & that physicians prescribe less than a 1-week supply to potentially suicidal patients.