The changes in pattern of drug use in self-poisoning were reviewed & their consequences assessed. Benzodiazepines increased markedly to 40% of patients admitted while barbituates declined from 30% to 15%. Tricyclic antidepressants saw a slow increase. The pattern showed a reduction in number & severity of patients admitted unconscious, in proportional terms. However, there is a continued rise in number of admissions for self-poisoning.