Increased Serotonin-2 Binding Sites in Frontal Cortex of Suicide Victims.

Differences in Serotonin-2(5-HT2) receptor properties were studied in frontal cortex from suicide victims and controls. The number of 5-HT2 receptors was significantly higher(44%)in the suicide group.The postsynaptic receptor changes were consistent with previous findings of a reduced number of presynaptic serotonin receptors in the same post-mortem series. The combined findings of both studies support the decreased use of serotonin in suicide victims and may also throw light on antidepressants.