Year: 1980 Source: Archives of General Psychiatry, v.37, no.7, (July 1980), p.761-767 SIEC No: 19820447

19 depressed patients had significantly higher cerebrospinal fluid (CSF) cortisol levels than did 30 healthy controls. In 12 obsessive-compulsive & 12 depressed subjects treated with clomipramine hydrochloride, the levels were significantly reduced. Cortisol levels in CSF were significantly correlated with mean urinary cortisol excretion.