Background: The emotion disgust is typically directed toward stimuli in the external environment, but sometimes people develop self-directed disgust responses. Aims: The current questionnaire study focused on the role of self-disgust in lifetime suicidal ideation and behavior. Method: A total of 1,167 individuals participated in an Internet-based survey containing self-report measures of self-disgust, externally directed disgust proneness, coping styles, diagnoses of mental disorders, and suicide risk. Hierarchical regression analyses as well as mediation analyses were computed. Results: Self-disgust was the most relevant predictor of suicide risk among the assessed variables. Self-disgust was negatively associated with the use of support by others, and positively associated with evasive coping (self-blame, venting, denial), which in turn was positively associated with suicidality. Limitations: This cross-sectional study provided information on the relationship between self-disgust and suicidality in a self-selected sample. Longitudinal studies are warranted. Conclusion: Future studies are required to replicate these findings. Additionally, stronger research designs are needed in order to investigate whether self-disgust should be targeted in suicide prevention programs and interventions.