Abstract
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression
Sokolov, A.V., Manu, D-M., Nordberg, D.O.T., Bostrom, A.DE., Jokinen J., Schioth, H.B.
Depression is a multifactorial disorder representing a significant public health burden. Previous studies have linked multiple single nucleotide polymorphisms with depressive phenotypes and suicidal behavior. MAD1L1 is a mitosis metaphase checkpoint protein that has been linked to depression in GWAS. Using a longitudinal EWAS approach in an adolescent cohort at two time points (n = 216 and n = 154), we identified differentially methylated sites that were associated with depression-related genetic variants in MAD1L1.