Male depression has been recognized as an important factor in some cases of intimate partner violence but there is a paucity of literature connecting depression and intimate partner homicide (IPH). This retrospective study provides a preliminary analysis that distinguished depressed from nondepressed perpetrators of IPH from a sample of 135 cases analyzed by a coroner’s homicide death review committee in Ontario, Canada. Depressed perpetrators were more likely to commit homicide-suicide and had almost 1.5 times the number of risk factors present than nondepressed perpetrators. Consistent with the existing literature, the results indicated that depressed perpetrators were significantly older, more likely to commit homicide-suicide than homicide only, more likely to have prior threats or attempts of suicide, more likely to have been abused or witnessed domestic violence as a child than nondepressed perpetrators and more likely to exhibit sexual jealousy. The implications for these findings are outlined in terms of training of mental health professionals and public awareness about the potential lethality of domestic violence.