In an editorial in this journal some years ago, Mann (2005) suggested that brain imaging is a promising direction for measuring the predisposition toward suicidal behavior. Since then, there has been a proliferation of imaging studies in both psychiatry and neuroscience, reflecting the increasing popularity of brain-disease models of psychiatric disorders. The hope is that neuroimaging research will contribute to evidence-based practice and lead to more refined diagnostics and the targeted treatment of these disorders (Borgelt, Buchman, & Illes, 2012).