Adolescence is a time of change; it’s exciting, exhilarating, and often requires support. It’s a period when youth are developing their capacity for self-direction.1 For many young people, the transition from childhood to adulthood can be challenging, yet we know it is also a period full of promise and opportunity, when we can intervene to make sure kids are on the right path. This report highlights the increasing impact of drugs, alcohol, and suicide on adolescents—trends that are extremely concerning and problematic. Yet research and on-the-ground programs demonstrate that we can reduce adolescent substance use and suicide. Solutions are available, and communities are willing and able to take on these challenges. This report shines a light on the policies and programs that work and offers recommendations for meaningful action.