Resource Tag: UNITED STATES. MARYLAND

OBJECTIVES: To assess whether the use of firearms explains rural-urban differences in suicide rates. METHODS: We performed a retrospective analysis on all 6196 well-characterized adult suicides in Maryland from 2003 through 2015. We computed rate ratios by using census data and then stratified by sex, with adjustment for age and race. RESULTS: Suicide rates were […]

Using a longitudinal study design with a community sample of more than 3,000 participants, the authors examined if hopelessness was a long-term predictor of suicidal behaviours. The association of hopelessness at baseline & incident suicidal behaviours in the 13-year follow-up was assessed, adjusting for depression & substance use disorders. Hopelessness was predictive of suicide, suicide […]

In this study, the age-adjusted incidence of suicide ideation was highest among current smokers, followed by former, then never smokers. The adjusted hazard for suicide ideation was 2.22 & 1.19 for current & former smokers, respectively, compared to never smokers. Results indicate that current smokers have increased risks of suicide ideation above & beyond the […]

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The objective of this study was to examine if changes in protein kinase A activity or in the protein & messenger RNA expression of any of its subunits are related to the pathophysiology of teenage suicide. The sample included 17 suicide victims & 17 nonpsychiatric control subjects. Protein kinase A activity was significantly decreased in […]

This study sought to determine if the presence of an anxiety disorder was a risk factor for future suicide attempts. Data were drawn from the 13-year follow-up Baltimore Epidemiological Catchment Area survey. The presence of one or more anxiety disorders at baseline was significantly associated with subsequent onset suicide attempts after controlling for sociodemographic variables […]

This study explored correlates of suicide ideation among African Americans in a community-based cohort in Baltimore, Maryland. Participants had begun to use heroin, crack, or cocaine by means other than injection in the prior 10 years. An interview-administered questionnaire was used. Multiple logistic regression was used to identify factors independently associated with suicide ideation. The […]

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Context  Depression is a major public health problem. Despite many years of research, the molecular mechanisms associated with depression remain unclear. Rap-1, activated in response to many extracellular stimuli, is one of the major substrates of protein kinase A, which participates in myriad physiologic functions in the brain, including cell survival and synaptic plasticity. Rap-1 […]

Background  Cyclic adenosine monophosphate response element binding protein (CREB) is a transcription factor that, on phosphorylation by protein kinases, is activated, and in response, regulates the transcription of many neuronally expressed genes. In view of the recent observations that catalytic properties and/or expression of many kinases that mediate their physiological responses through the activation of […]

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The authors evaluated the system of firearm-related injury surveillance extant in Maryland to evaluate its ability to ascertain cases in the absence of a standard for the true number of cases. They found that the system was highly sensitive & had a very high positive predictive value. (4 refs)

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Published in “Back to the Future: Refocusing the Image of Suicide,” ed. by J L McIntosh

This paper reviews the phenomenon of adolescent suicide & offers a case study on the use of rapid & efficient group crisis intervention, referred to as a Crisis Management Briefing, directed towards the vicarious victims of an adolescent suicide attempt. (10 refs)

This document summarizes a study that identified psychiatric risk factors of suicide ideation, attempted suicide, & completed suicide in a longitudinal, community-based setting using data from the Baltimore Epidemiologic Catchment Area Program.

The present study was performed to examine whether the expression of brain-derived neurotrophic factor (BDNF) &/or activating receptor tyrosine kinase B (trk B) isoforms was altered in postmortem brain in subjects who complete suicide & whether these alterations were associated with specific psychopathologic conditions. Message RNA levels of BDNF & trk B were significantly reduced […]

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