Suicidal thinking and behavior in first episode schizophrenia: Findings from the 24-month follow-up of the “Parma Early Psychosis” program

Although suicide risk is relevant in First Episode Schizophrenia (FES), little data are reported on suicidal ideation and its longitudinal stability. Aim of this study was: (1) to evaluate incidence rates of suicide attempts, completed suicide and suicidal thinking in FES patients at baseline and along a 24-month follow-up period, (2) to investigate any relevant […]

Risks of all-cause death and completed suicide in patients with schizophrenia/schizoaffective disorder treated with long-acting injectable or oral antipsychotics: A population-based retrospective cohort study in Taiwan

Background: Long-acting injectable (LAI) antipsychotics improve medication adherence in patients with schizophrenia and extend the duration of therapeutic drug levels but with administration of an increased dose. Real-world mortality data in patients prescribed LAIs are lacking. We conducted a population-based cohort study to estimate and compare the incidence rates of all-cause death and completed suicide […]

Comparative effectiveness of antipsychotics for risk of attempted or completed suicide among persons with schizophrenia

Objective The objective of our study was to investigate the comparative effectiveness of antipsychotics for the risk of attempted or completed suicide among all patients with schizophrenia in Finland and Sweden. Methods Two nationwide register-based cohort studies were conducted, including all individuals with schizophrenia in Finland (n = 61 889) and Sweden (n=29 823). The main […]

The importance of suicide risk formulation in schizophrenia

Suicide is a cause of early mortality in nearly 5% of patients with schizophrenia, and 25–50% of patients with schizophrenia attempt suicide in their lifetime. Evidence points to numerous individual, clinical, social, and psychological risk factors for suicide in patients with schizophrenia. Although recognizing suicidal risk factors in schizophrenia is extremely important in suicidal risk […]

Suicide and psychosis: Results from a population-based cohort of suicide death (N=4380)

Approximately 5% of individuals with schizophrenia die from suicide. However, suicide in psychosis is still poorly characterized, partly due to a lack of adequate population-based clinical or genetic data on suicide death. The Utah Suicide Genetics Research Study (USGRS) provides a large population-based cohort of suicide deaths with medical record and genome-wide data (N = 4380). […]

Affective theory of the mind and suicide in women with borderline personality disorder and schizophrenia: A comparative study

Background Theory of mind (ToM) is one of the essential components of social cognition. Affective ToM enables us to interpret other’s feelings and behaviors. Borderline personality disorder (BPD) and schizophrenia are two distinct mental disorders, yet they have a mutual deficit in interpreting emotions, thoughts, and intentions which may lead to a higher incidence of […]

Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis

Suicide attempts (SA) frequently occur in patients with mood disorders and schizophrenia, which are both accompanied by activated immune-inflammatory and nitro-oxidative (IO&NS) pathways. Methods We searched PubMed, Google Scholar, and Web of Science, for articles published from inception until February 1, 2021. We included studies that compared blood biomarkers in psychiatric patients with (SA+) and […]

Characteristics and risk factors for suicide in people with schizophrenia in comparison to those without schizophrenia

Background Little research has been conducted that compares suicide cases with and without schizophrenia. The aim of the present study was to identify demographic, personal, social, relational, and psychological characteristics among suicides identified posthumously with schizophrenia compared to those without. Methods The DSM-IV was used to independently assess the presence of schizophrenia among suicide cases […]

Suicide risk in Medicare patients with schizophrenia across the life span

Objective  To describe suicide mortality rates and correlates among adults with schizophrenia across the life span and standardized mortality ratios (SMRs) for suicide compared with the general US population. Design, Setting, and Participants  Five national retrospective longitudinal cohorts of patients with schizophrenia in the Medicare program from January 1, 2007, to December 31, 2016, were identified by […]

A comprehensive review of computer-aided diagnosis of major mental and neurological disorders and suicide: A biostatistical perspective on data mining

The World Health Organization (WHO) suggests that mental disorders, neurological disorders, and suicide are growing causes of morbidity. Depressive disorders, schizophrenia, bipolar disorder, Alzheimer’s disease, and other dementias account for 1.84%, 0.60%, 0.33%, and 1.00% of total Disability Adjusted Life Years (DALYs). Furthermore, suicide, the 15th leading cause of death worldwide, could be linked to […]

Mobile texting and lay health supporters to improve schizophrenia care in a resource-poor community in rural China (LEAN Trial): Randomized controlled trial extended implementation

Background: Schizophrenia is a severe and disabling condition that presents a dire health equity challenge. Our initial 6-month trial (previously reported) using mobile texting and lay health supporters, called LEAN, significantly improved medication adherence from 0.48 to 0.61 (adjusted mean 0.11, 95% CI 0.03 to 0.20, P=.007) for adults with schizophrenia living in a resource-poor village in […]

Comparisons between suicide in persons with serious mental illness, other mental disorders, or no known mental illness: Results from 37 U.S. states, 2003-2017

Background Suicide is a leading cause of death in persons with schizophrenia and other serious mental illnesses (SMI), however, little is known about the characteristics and circumstances of suicide decedents with SMI in the US compared to those with other or no known mental illness. Methods This study was a retrospective analysis of suicide deaths […]

Increased risk of COVID-19 infection and mortality in people with mental disorders: Analysis from electronic health records in the United States

Concerns have been expressed that persons with a pre‐existing mental disorder may represent a population at increased risk for COVID‐19 infection and with a higher likelihood of adverse outcomes of the infection, but there is no systematic research evidence in this respect. This study assessed the impact of a recent (within past year) diagnosis of […]

Suicide risk after psychiatric discharge: Study protocol of a naturalistic, long-term, prospective observational study

Background Suicide risk of psychiatric patients has proven to be strongly increased in the months after discharge from a psychiatric hospital. Despite this high risk, there is a lack of systematic research on the causes of this elevated suicide risk as well as a lack of treatment and intervention for patients at high risk after […]

Predictors of suicide at time of diagnosis in schizophrenia spectrum disorder: A 20-year total population study in Ontario, Canada

Background Suicide is a major cause of mortality for individuals with schizophrenia spectrum disorders (SSD). Understanding the risk factors for suicide at time of diagnosis can aid clinicians in identifying people at risk. Methods Records from linked administrative health databases in Ontario, Canada were used to identify individuals aged 16 through 45 years who received a […]

Significance of depression and schizophrenia for suicide: A review of the literature

People with diagnosed mental disorders have increased risk of suicide. The relevance of suicide problem these days is undeniable. Suicide is the second most common death cause for people aged 18 – 29, 1,4% of world population died from suicide, suicide is 18th most common death cause worldwide. Most of suicides worldwide are related to […]

Feasibility and correlations of smartphone meta-data toward dynamic understanding of depression and suicide risk in schizophrenia

Objectives We investigate whether meta‐data, specifically duration of responses to smartphone‐delivered surveys, is correlated to elevated scores on the depression assessment PHQ‐9 as well as the specific item around self‐harm (item 9). Methods In this observational study, we recruited 92 smartphone‐owning adults (≥ 18) with schizophrenia (45) and healthy controls (43). We installed an open‐source smartphone […]

Suicide ideation and behavior as risk factors for subsequent suicide in schizophrenia: A nested case-control study

Objective To investigate suicide ideation and behavior as risk factors for suicide in schizophrenia during varying time periods. Method Cases were 84 patients who died by suicide within 5 years from diagnosis in a source population of patients discharged for the first time from psychiatric hospitals in Stockholm County, Sweden, with a schizophrenia spectrum diagnosis. One […]

Suicidal ideation and behaviour in patients with persecutory delusions: Prevalance, symptom associations, and psychological correlates.

Background To determine the prevalence of suicidal ideation and behaviour – and their correlates – in patients with persecutory delusions. Methods 110 patients with persecutory delusions in the context of non-affective psychosis were assessed for suicidal thoughts and behaviours over the past month. Symptom and psychological assessments were also completed. Results The severity of suicidal […]

Beyond the mental pain: A case-control study on the contribution of schizoid personality disorder symptoms to medically serious suicide attempts

Background Clinical and research findings have highlighted the role of interpersonal factors in suicidal behavior with high levels of intent and lethality. Schizoid personality disorder (SPD) is at the extreme end of interpersonal difficulties. Thus, we aimed to understand the contribution of SPD symptoms to suicide behavior and specifically to more lethal suicide attempts. Method Four groups were investigated (N = 338): medically […]

Self-stigma mediates the impact of insight on current suicide ideation in suicide attempters with schizophrenia: Results of a moderated mediation approach

This study examined the relationships among insight, self‐stigma, self‐esteem, hope, quality of life, and suicidal behavior in individuals diagnosed as having schizophrenia. Hypotheses concerning mediating and moderating effects were examined. A total of 170 community‐dwelling patients with schizophrenia participated in the study. The results revealed a negative association between insight and suicide ideation, which was […]

Undetected autism subthreshold spectrum as risk factor for suicidal gestures in adulthood: A case report.

Autism Spectrum Disorder (ASD) has been recently highlighted as potentially related to a higher risk for suicide. ASD features are often under-recognized, especially in subjects with high level of functioning. We present the case of a 21-year-old man who attempted suicide jumping from the third floor of his home. The patient had been treated during […]

Serum cholesterol and suicide in the first episode psychosis: A preliminary study.

Background: Low levels of cholesterol have been described in suicide behavior including among those individuals who have an increased tendency for impulsivity. Violent suicide attempters show significantly lower cholesterol levels than nonviolent suicide attempters. The suicide rate is particularly high in the prodromal and early phase of schizophrenia. It is unclear if there is a psychopathological […]