Evaluation of factors related to overdose in patients with impaired consciousness who are transported by emergency medical services: An age-specific research

Background: Drug overdose accounts for most of the admissions to the emergency department. Prescription drugs, most of which are psychotropic medications, are often misused for drug overdose. The purpose of this study was to investigate the association between overdose in patients transported with disorders of consciousness and psychotropic medications administered prior to transport, so as to […]

Psychiatric medication intake in suicide victims: Gender disparities and implications for suicide prevention

Frequency and gender differences of psychiatric medication intake in a sample of suicide victims from the Athens Greater Area were investigated with a particular focus on the implications for suicide prevention. Data were collected from the toxicological analyses of the suicide cases of the period November 2007-October 2009. Information was available for 262 individuals, 196 […]

The impact of parental injury on children’s mental health diagnoses and classes of psychotropic medication by child age

Background Civilian and military research has linked parental illness and injury with increased overall mental health care and psychiatric medication use in children. Care for specific mental health conditions and medications by child age have not been reported. Objective We sought to quantify the effect of parental illness and injury on child mental health care […]

Suicide mortality and use of psychotropic drugs in patients hospitalized due to bipolar disorder: A Finnish nationwide cohort study

Background Knowledge on the comparative effectiveness of pharmacological treatments to prevent suicide mortality in bipolar disorder is still lacking. Methods We studied the risk of suicide mortality during 1996–2012 among all patients who had been hospitalized due to bipolar disorder in Finland (n = 18,018; mean follow-up time 7.2 years) using nation-wide databases. We used a Cox […]

Suicide attempts by drug overdose at Jichi Medical University Hospital emergency centre: A study of patient characteristics and quantity of drug overdose

Objective Patients attempted suicide by psychotropic drug overdose and require medical care have increased, becoming a serious problem in Japan. This study investigated the characteristics of patients who attempted suicide by overdose and required emergency care, with a focus on quantity of drugs taken. Methods We conducted a clinical survey of 98 patients examined at […]

Use of prescription medication by individuals who died by suicide in Northern Ireland.

To understand medication use prior to suicide in relation to patterns, polypharmacy, and adherence. A total of 1,371 suicide cases were coded and latent class analysis used to identify combinations of medications prescribed prior to death. Two thirds had been prescribed medication with 30.7% prescribed 3 or more. Latent class analysis revealed three classes: Mixed […]

Antidepressants and suicidal ideation in adolescence: a paradoxical effect.

The past two decades have seen a rapid increase in the number and types of psychopharmacological medications that are available for the treatment of depression in children and adolescents. Parents and adolescents often raise questions as to the potential increase in suicidal ideation associated with the use of primarily selective serotonin reuptake inhibitors (SSRIs). This […]

Young people’s risk of suicide attempts after contact with a psychiatric department – a nested case-control design using Danish register data.

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Ketamine for the treatment of depression.

Ketamine (Ketalar¨) is an anesthetic agent derived from the hallucinogenic drug phencyclidine (PCP). It is a high-affinity antagonist at N-methyl-D-aspartate receptors and also binds to opioid mu and sigma receptors. Ketamine is being intensively investigated as an antidepressant therapy. To date, five short-term controlled studies and other open-label studies in patients with unipolar or bipolar […]

Suicidality as rare adverse event of antidepressant medication: report from the AMSP Multicenter Drug Safety Surveillance Project.

Objective: Since the advent of antidepressant drug treatment, the question of whether these substances induce suicidal ideation and behavior has not been satisfactorily answered. The aim of this study is to contribute to this ongoing discussion by taking a heuristic case-based approach to the question. Method: A large data set from a European drug surveillance […]

Pharmacotherapy: Lithium and ALS, Levodopa and Neuropathy, Antiepileptic Drugs and Suicide

This article discusses recently published research in other journals including a study on suicide-related events in patients treated with antiepileptic drugs. The study found that current use of antiepileptic drugs was not associated with an increased risk of suicidal behaviours among patients with epilepsy but did increase risk among patients who received these drugs & […]

Suicides by Drug Poisoning Among the Elderly in Sweden 1969-1996

This study examined whether altered prescription patterns are associated with changes in the rates of drug-related suicides in Swedish elderly. An ecological study was performed in which rates of suicide by drug poisoning were related to prescription sales of different psychotropic drugs. Rates of suicide using benzodiazepines increased despite decreasing prescription sales. Decreasing tricyclic antidepressant […]

Update on the Toxicology of Suicide

This article reviews the literature on the toxicology of suicide. Although toxicologic investigations are considered an integral part of medical-forensic investigations in individual cases of suicide, very few American states require comprehensive toxicology on all suicide victims. Instead, subjective determinations for toxicologic testing based on local policy & individual coroner or medical examiner preference are […]

Increased use of Medicinal Drugs in Self-Harm in Urban Areas in Sri Lanka

This study described substances used in overdose & the characteristics of patients admitted with medicinal drug overdose in an urban tertiary care hospital in Colombo. A descriptive study of 191 patients admitted with intentional self-poisoning was carried out. Medicinal drugs were the most common substance used in overdose. Those who used medicinal drugs were mainly […]

Psychotropic Prescriptions and Elderly Suicide Rates

The association between a decline in elderly suicide rates in England & Wales & changes in the prescribing of psychotropics for the period 1985-1996 was studied. Spearman’s rank correlation coefficient was used to examine this relationship. Highly significant negative correlations were found between elderly suicide rates & tricyclic antidepressants, selective serotonin reuptake inhibitors, antimanics, antipsychotics, […]

The Impact of Trends in Psychotropic Prescribing on the Method of Suicide in the Elderly

This study examined the relationship between prescribing patterns of individual psychotropic drugs & suicide rates by specific methods among the elderly. There was a negative correlation between the prescription of tricyclic antidepressants, selective serotonin reuptake inhibitors, antipsychotics, antimanic drugs, & nonopiate analgesics & a decline in elderly suicides by poisoning, hanging, strangulation, drowning, firearms, & […]

Relationship Between Antiepileptic Drugs and Suicide Attempts in Patients With Bipolar Disorder

The objective of this study was to determine if antiepileptic drugs increase the risk of suicide attempt in patients with bipolar disorder. The study included a cohort of 47,918 patients with bipolar disorder with a minimum 1-year window of information before & after the index date of their illness. Overall, there was no significant difference […]

Are Sedatives and Hypnotics Associated With Increased Suicide Risk of Suicide in the Elderly?

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Patterns of Concomitant Psychotropic Medication use During a 2-Year Study Comparing Clozapine and Olanzapine for the Prevention of Suicidal Behavior

In this study, 479 patients received clozapine & 477 patients received olanzapine. Concomitant psychotropic medications were grouped into 4 classes: antipsychotics, antidepressants, sedatives/anxiolytics, & mood stabilizers. An analysis of covariance was performed to compare mean daily doses of concomitant psychotropic medications between the 2 groups over the 2-year treatment period. For each class, the mean […]

Reduced Suicidal Ideation in Bipolar I Disorder Mixed-Episode Patients in a Placebo-Controlled Trial of Olanzapine Combined With Lithium or Divalproex

Symptoms associated with suicidality in bipolar I patients were identified & suicide risk during treatment with olanzapine in combination with lithium or divalproex was assessed. Data were used from a previous study in which patients with bipolar I manic or mixed-episode who were partially responsive to at least 2 weeks of lithium or divalproex monotherapy […]

The Relationship Between Elderly Suicide Rates and the Affordability of Psychotropic Drugs

In this letter to the editor, the authors discuss a cross-national study they did to examine the relationship between elderly suicide rates & the affordability of psychotropic medications. Contrary to earlier reports which found a decline in elderly suicide rates with an increase in prescription rates of antidepressants, an absence of correlation between the affordability […]

The Role of Benzodiazepines in Elderly Suicides

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Suicidal Ideation and Pharmacotherapy Among STEP-BD Patients