Increased C-reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta-analysis

Objective: Suicide is a leading cause of death worldwide. Identifying factors associated with suicidality (suicidal ideation [SI]/suicidal behavior) could increase our understanding of the pathophysiological underpinnings of suicide and improve its prevention. Methods: We conducted a systematic review (PubMed/PsycInfo/Cochrane databases, up to September 2020) and random-effect meta-analysis including observational studies comparing peripheral C-reactive protein (CRP) levels in […]

Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans

Introduction: The U.S. suicide mortality rate has steadily increased during the past two decades, particularly among military veterans; however, the epigenetic basis of suicidal thoughts and behaviors (STB) remains largely unknown. Methods: To address this issue, we conducted an epigenome-wide association study of DNA methylation (DNAm) of peripheral blood samples obtained from 2,712 U.S. military veterans. Results: Three […]

Depression and suicidality: The roles of social support and positive mental health

Objective: Despite being preventable, suicide remains a leading cause of death globally, with depression being one of the more prominent risk factors. This study examines the roles of social support and positive mental health in the depression-suicidality pathway. Methods: We utilized data from the Singapore Mental Health Study 2016. Social support and positive mental health […]

The knowledge and awareness of suicide and attitudes towards its risks in university students of Asir region of Saudi Arabia

Background: Suicide is defined as the deliberate ending of one’s own life or a deadly self-injurious act with evidence of the intention to die. Suicide among youths is a significant public mental health issue. Young individuals, particularly adolescents, are naturally susceptible to mental health problems. Methods: The present study has the cross-sectional study design based on simple random […]

Psychiatric patient disposition agreement between the emergency physician and the psychiatry consultant

Background: Mental illness is prevalent, disabling, and costly. Emergency department (ED) visits for mental health-related reasons are on the increase. Aims: Determine the level of agreement between emergency physicians and psychiatrists regarding psychiatric patient disposition. Method: We conducted a prospective, observational study at a private university hospital ED from October 2008-April 2009 using a convenience sample of patients […]

Investigation of the relationship between psychiatry visit and suicide after deliberate self-harm: Longitudinal national cohort study

Background: Deliberate self-harm (DSH) along with old age, physical disability, and low socioeconomic status are well-known contributors to suicide-related deaths. In recent years, South Korea has the highest suicide death rate among all Organization for Economic Co-operation and Development countries. Owing to the difficulty of accessing data of individuals with DSH behavior who died by […]

Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt: A cross-sectional study of suicide attempters

Background The ability to accurately estimate risk of suicide deaths on an individual level remains elusive. Methods This study reports on a case-control study set-up from a well-characterized cohort of 88 predominantly female suicide attempters (SA), stratified into low- (n = 57) and high-risk groups (n = 31) based on reports of later death by suicide, as well as […]

Results of the COVID‑19 mental health international for the health professionals (COMET‑HP) study: depression, suicidal tendencies and conspiracism

Introduction The current study aimed to investigate the rates of anxiety, clinical depression, and suicidality and their changes in health professionals during the COVID-19 outbreak. Materials and methods The data came from the larger COMET-G study. The study sample includes 12,792 health professionals from 40 countries (62.40% women aged 39.76 ± 11.70; 36.81% men aged 35.91 ± 11.00 and […]

Analysis of psychiatric symptoms and suicide risk among younger adults in China by gender identity and sexual orientation

Importance  Younger adults in China who are transgender and gender nonconforming (TGNC) and lesbian, gay, and bisexual (LGB) experience high levels of minority stress (eg, stigma and bullying) and adverse mental health symptoms. However, there is a lack of research documenting mental health disparities compared with their cisgender and heterosexual peers. Studies that disaggregate TGNC and […]

Perspectives on reasons for suicidal behaviour and recommendations for suicide prevention in Kenya: Qualitative study

Background: Little is known about the reasons for suicidal behaviour in Africa, and communities’ perception of suicide prevention. A contextualised understanding of these reasons is important in guiding the implementation of potential suicide prevention interventions in specific settings. Aims: To understand ideas, experiences and opinions on reasons contributing to suicidal behaviour in the Coast region […]

Genetic differences between suicide deaths and deaths of undetermined intent

Introduction Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. Methods The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) […]

Moral distress experienced by online suicide prevention volunteers: Qualitative research

Background: With the increasing number of internet users, it becomes feasible to identify individuals at high risk of suicide and then carry out online suicide prevention. At the same time, online suicide prevention volunteers may encounter moral distress, which requires more attention. Purpose: This study aimed to explore the experience of moral distress in online […]

Suicide hangings during pre-Covid-19 and Covid-19: Myths debunked for the lower-middle-income group countries

The psyche about the adverse effects of the Covid-19 pandemic has got fixed to a level of conviction that committing suicide is directly linked to coronavirus infection. The statistics of suicidal hangings for the pre-Covid-19 and the Covid-19 periods were compared in the Indian capital. The data analysis of the autopsy records showed the absence […]

The relationship between attachment and self-injurious behaviors in the child and adolescent population: A systematic review of the literature

Adolescents have high rates of self-injurious behavior (SIB), with suicide being the second leading cause of death. A consistent relationship between individual attachment and SIB was previously found in adult population; however, no such review has been undertaken for the child and adolescent population. A systematic search of PubMED, OVID, and PsychINFO up to March […]

Suicide attempts among Greenlandic forensic psychiatric patients: Prevalence and determinants

This nationwide cross-sectional study of the lifetime prevalence and determinants of suicide attempts includes 90% of Greenlandic forensic psychiatric patients. Retrospective data were collected from electronic patient files, court documents, and forensic psychiatric assessments using a coding form from a similar study. We used unpaired t-tests and chi2 or Fisher’s exact test. The lifetime prevalence of […]

Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis

Suicide attempts (SA) frequently occur in patients with mood disorders and schizophrenia, which are both accompanied by activated immune-inflammatory and nitro-oxidative (IO&NS) pathways. Methods We searched PubMed, Google Scholar, and Web of Science, for articles published from inception until February 1, 2021. We included studies that compared blood biomarkers in psychiatric patients with (SA+) and […]

Experiences of a recovery-oriented caring approach to suicidal behavior: A single-case study

Research considering the basis for mental health nurses wanting to enable recovery among people who suffer from suicidal behavior is sparse. The aim of this study is to explore and evaluate how a new recovery-oriented caring approach (ROCA) was experienced by a suicidal patient in a context of close relatives and nurses. A single-case study […]

Outreach psychiatric emergency service: Characteristics of patients with suicidal behavior and subsequent policy

Background: Outreach psychiatric emergency services play an important role in all stages of a suicidal crisis; however, empirical assessment data are scarce. This study describes characteristics of patients assessed by these services and involved in suicidal crises. Method: During a 5-year period, detailed information from psychiatric emergency service assessments was recorded; 14,705 assessments were included. […]

The third choice: Suicide hotlines, psychiatry, and the police

With Covid-19 showing no sign of abating, mental health care (from ongoing therapy to helplines) continues to be an important site of treatment for many Americans. While traditional therapy has continued to be prohibitively expensive for most, teletherapy has been covered by most major health insurance companies since the early days of the pandemic and is […]

Effect of a motivational interviewing-based intervention on initiation of mental health treatment and mental health after an emergency department visits among suicidal adolescents: A randomized clinical trial

OBJECTIVE To examine whether a motivational interviewing–based intervention increases linkage of adolescents to outpatient mental health services and reduces depression symptoms and suicidal ideation in adolescents seeking emergency care for non–mental health–related concerns who screen positive for suicide risk. DESIGN, SETTING, AND PARTICIPANTS In this randomized clinical trial, adolescents aged 12 to 17 years who […]

Exposure to maternal depressive symptoms in childhood and adolescent suicide-related thoughts and attempts: Mediation by child psychiatric symptoms

Aims. The nature of the association between child psychiatric symptoms and adolescent suicide-related thoughts (SRT) and attempts (SA) remains unclear. Our objective was to assess whether child psychiatric symptoms from 6 to 10 years of age mediate the association between exposure to maternal depressive symptoms in childhood and offspring SRT and SA in adolescence. Methods. […]

Impact of oil recession on community mental health service utilization in an oil sands mining region in Canada.

Objectives: This retrospective clinical audit compared changes in community mental health service utilization before and during an economic recession in an oil sands region in Canada which was characterized by a doubling of unemployment rates and poor economic outlook. Methods: Sociodemographic descriptors, psychiatric antecedents, clinical characteristics and follow-up care were compared before and during the […]

Precursors to suicidality and violence on antidepressants: Systematic review of trials in adult healthy volunteers.

OBJECTIVE: To quantify the risk of suicidality and violence when selective serotonin and serotonin-norepinephrine reuptake inhibitors are given to adult healthy volunteers with no signs of a mental disorder. DESIGN: Systematic review and meta-analysis. MAIN OUTCOME MEASURE: Harms related to suicidality, hostility, activation events, psychotic events and mood disturbances. SETTING: Published trials identified by searching […]