The effect of long-term stress on hippocampus and the involvement in the pathophysiological and psychological disorders, suicide, and alcohol use disorder

The hyperactivity of the HPA axis due to long-term stress results in an abnormally high level of glucocorticoids. A limbic system structure, the hippocampus has the highest number of receptor sites for glucocorticoids. Thus, making it highly vulnerable to damage during elevated levels of glucocorticoids, through neurotoxicity and metabolic challenges. In addition, this paper largely[…]

A nationwide cohort study of the association between hospitalization with infection and risk of death by suicide.