Prospective investigation of the interaction between social problems and neuropsychological characteristics on the development of suicidal ideation

Objective Negative social interactions are known to contribute to the development of suicide ideation. However, it is unclear how this risk factor interacts with other predisposing risk factors. The purpose of this study was to determine how social and neuropsychological factors interact as a prospective predictor of the emergence of suicide ideation in adolescents. Method […]

Suicide ideation and neurocognition among 9- and 10-year old children in the Adolescent Brain Cognitive Development (ABCD) Study

During the past decade, the pediatric suicide rate has nearly tripled. Yet, little is known about suicide behavior (SB) in children. Identification of risk factors associated with SB during childhood may be critical to preventing future attempts. The purpose of this study was to examine the relationship between neurocognitive performance and suicide ideation (SI) in […]

Neurocognitive functioning adolescents at risk for suicidal behaviors

Today, little is still known about the neurocognitive functioning of the individual at risk for suicide in a relevant developmental stage like adolescence. Thus, the main goal of the present work was to analyze the neurocognitive performance of adolescents at high risk for suicide. A total of 1509 adolescents from a stratified random cluster sampling […]

The impact of COVID-19 on mental, neurological and substance use services: Results of a rapid assessment

This report of a survey completed by 130 countries during the period June-August 2020 provides information about the extent of disruption to mental, neurological and substance use services due to COVID-19, the types of services that have been disrupted, and how countries are adapting to overcome these challenges.

Prefrontal activity during experimental ostracism and daily psychache in suicide attempters

Background Suicidal behaviors can result from a complex interaction between social stressors and individual vulnerability. Evidence suggests a specific neural processing of social cues in suicide attempters without knowledge of how it relates to real-world experiences. Objective To investigate the association between brain activity during experimental social exclusion (measured by functional MRI) and psychological pain in […]

Decision-making and cognitive control in adolescent suicidal behaviors: A qualitative systematic review of the literature

Suicide and suicidal behaviors represent a leading cause of morbidity and mortality during adolescence. While several lines of evidence suggest that suicidal behaviors are associated with risky decisions and deficient cognitive control in laboratory tasks in adults, comparatively less is known about adolescents. Here, we systematically reviewed the literature on the association between these neurocognitive […]

Evaluation of BDNF as a biomarker for impulsivity in a psychiatric population

Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation. In this study, brain-derived neurotrophic factor (BDNF), a nerve growth factor, was evaluated as a potential biomarker for impulsivity. We hypothesize that elevated […]

The neuroscience of suicidal behavior

Nearly one million people take their own lives each year world-wide – however, contrary to popular belief, suicide can be prevented. While suicide is commonly thought to be an understandable reaction to severe stress, it is actually an abnormal reaction to regular situations. Something more than unbearable stress is needed to explain suicide, and neuroscience […]

Imaging suicidal thoughts and behaviors: A comprehensive review of 2 decades of neuroimaging studies

Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within […]

Machine learning of neural representations of suicide and emotion concepts identifies suicidal youth

The clinical assessment of suicidal risk would be substantially complemented by a biologically based measure that assesses alterations in the neural representations of concepts related to death and life in people who engage in suicidal ideation. This study used machine-learning algorithms (Gaussian Naive Bayes) to identify such individuals (17 suicidal ideators versus 17 controls) with […]

Neurocognitive function and suicide in U.S. Army soldiers.

This prospective cohort study used administrative data from the Army Study to Assess Risk and Resilience in Servicemembers to examine associations between neurocognitive functioning and subsequent suicidal events among Regular Army enlisted soldiers during the years 2004–2009. Cases were all soldiers who completed the Army’s Automated Neuropsychological Assessment Metrics (ANAM) computerized testing battery prior to […]

Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide.

Neuregulin-1 (NRG1) and ErbB receptors have been associated with psychopathology, and NRG1-ErbB3 signaling has been shown to increase hippocampal neurogenesis and induce antidepressant-like effects. In this study, we aimed to determine whether deficits in NRG1 or ErbBs might be present in the hippocampus of suicide completers. In well-characterized postmortem hippocampal samples from suicides and matched […]

Neuropsychological markers of suicidal risk in the context of medical rehabilitation.

While great strides have been made to advance the understanding of the neurobiology of suicidal behavior (SB), the neural and neuropsychological mechanisms associated with SB are not well understood. The purpose of the current study is to identify neurocognitive markers of SB in the context of medical rehabilitation. The performances of 39 patients at a […]

Neurocognitive alterations in first degree relatives of suicide completers.

Background: Suicide aggregates within families and the relatives of suicide completers are at an increased risk for suicide. Though neurocognitive changes are gaining increasing attention as part of the vulnerability for suicide, the literature on neurocognitive alterations among suicide relatives as possible endophenotypes of suicide is sparse. Method: Normothymic first-degree relatives (n¼14) of suicide completers […]

Neuropsychological function and suicidal behavior: attention control, memory and executive dysfunction in suicide attempt.

suicidal behavior. However, this dysfunction is not found consistently across samples. Method Medication-free subjects with DSM-IV major depressive episode (major depressive disorder and bipolar type I disorder) and a past history of suicidal behavior (n = 72) were compared to medication-free depressed subjects with no history of suicidal behavior (n = 80) and healthy volunteers […]