Suicide ideation and neurocognition among 9- and 10- year old children in the Adolescent Brain Cognitive Development (ABCD) study

Objective During the past decade, the pediatric suicide rate has nearly tripled. Yet, little is known about suicide behavior (SB) in children. Identification of risk factors associated with SB during childhood may be critical to preventing future attempts. The purpose of this study was to examine the relationship between neurocognitive performance and suicide ideation (SI) […]

Suicide risk screening in pediatric outpatient neurodevelopmental disabilities clinics

Objective: The purpose of this study was to describe the implementation of universal suicide risk screening in pediatric neurodevelopmental disabilities (NDD) medical clinics, analyze demographic and clinical characteristics of eligible patients, describe outcomes of positive screenings, and describe factors that influenced participation in screenings. Methods: A suicide risk screening protocol was developed and implemented for […]

Role of inflammation in suicide: From mechanisms to treatment

Suicidal behavior is complex and manifests because of a confluence of diverse factors. One such factor involves dysregulation of the immune system, which has been linked to the pathophysiology of suicidal behavior. This review will provide a brief description of suicidality and discuss the contribution of upstream and downstream factors in the etiology of suicidal […]

Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis

Suicide attempts (SA) frequently occur in patients with mood disorders and schizophrenia, which are both accompanied by activated immune-inflammatory and nitro-oxidative (IO&NS) pathways. Methods We searched PubMed, Google Scholar, and Web of Science, for articles published from inception until February 1, 2021. We included studies that compared blood biomarkers in psychiatric patients with (SA+) and […]

A comprehensive review of computer-aided diagnosis of major mental and neurological disorders and suicide: A biostatistical perspective on data mining

The World Health Organization (WHO) suggests that mental disorders, neurological disorders, and suicide are growing causes of morbidity. Depressive disorders, schizophrenia, bipolar disorder, Alzheimer’s disease, and other dementias account for 1.84%, 0.60%, 0.33%, and 1.00% of total Disability Adjusted Life Years (DALYs). Furthermore, suicide, the 15th leading cause of death worldwide, could be linked to […]

Evaluation of BDNF as a biomarker for impulsivity in a psychiatric population

Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation. In this study, brain-derived neurotrophic factor (BDNF), a nerve growth factor, was evaluated as a potential biomarker for impulsivity. We hypothesize that elevated […]

Prevention of suicide in persons with progressive neurological diseases

People suffering with neurological diseases are at risk of committing suicide. A case-control study found increased risk of attempted suicide in patients with nine chronic neurological diseases [1]. Similarly, people diagnosed with neurological disorders were twice as likely to die of suicide than people not diagnosed with such disorders [2]. This increased risk could be […]

Neural correlates of suicidality in adolescents with major depression: Resting-state functional connectivity of the precuneus and posterior cingulate cortex

Objective Major depressive disorder (MDD) is associated with suicidal thoughts and behaviors (“suicidality”). Of the three components of Joiner’s interpersonal theory of suicide, two involve negatively valenced, self‐related beliefs: perceived burdensomeness and thwarted belongingness. However, the neurocircuitry underlying self‐processing and suicidality has not been fully explored. This study examined the association between suicidality and the […]

Suicide in Dementia: 9-Year National Clinical Survey in England and Wales

File copy includes a data supplement table.

Dementia: Suicide by Drowning

In these letters to the editor, the authors comment on a study, published in 2009, by Purandare & colleagues on suicide in dementia. Questions are raised about the study design. The reply of Purandare & colleagues follows.

Early Dementia Diagnosis and the Risk of Suicide and Euthanasia

The authors performed a selective literature review of suicide in persons with dementia & the ethical issues associated with euthanasia in this population. In the absence of any effective treatments for Alzheimer’s disease or other types of dementia, there is already evidence that persons with mild cognitive change & early dementia are at risk of […]

Hospital-Diagnosed Dementia and Suicide: a Longitudinal Study Using Propsective, Nationwide Register Data

This study examined the risk of suicide in persons diagnosed with dementia during a hospitalization & its relationship to mood disorders. Event-history analysis using time-varying covariates was done of all individuals aged 50 & older living in Denmark during January 1990-December 2000. During the study period, 136 persons who previously had been diagnosed with dementia […]

Impulsive Suicide Attempts by a Patient With Alcoholic Dementia

This article presents the case of a 57-year-old male veteran with alcoholic dementia who made two suicide attempts in the hospital within a 2-hour period. (7 refs.)

Clinicopathological Findings of Suicide in the Elderly: Three Cases

The neuropathological correlates of suicide in older persons have received little research attention. The authors’ recent study of 143 elderly Australian suicide victims, unlike a previous case-control study, did not find an increased prevalence of Alzheimer’s disease despite a history of dementia in 6.3%. Clinicopathological data on 3 cases are presented. (56 refs.)

Types of Nursing Home Residents With Self-Destructive Behaviours: Analysis of the Harmful Behaviours Scale

This study investigated the types of self-destructive behaviours identified by the Harmful Behaviours Scale & the variables associated with them. A cross sectional survey involving 647 residents in 11 nursing homes in Sydney, Australia was conducted. Latent class analysis of the Harmful Behaviours Scale identified 4 groups, described as aggressive-resistant, food refusal, behaviourally disturbed, & […]

The Incurables

The Psychological Care of Medical Patients: a Practical Guide

Suicidal Thinking in Community Residents Over Eighty

A random sample of participants (age 81+) from a cohort in a pre-existing epidemiological study of dementia were selected for an interview. 125 of 170 eligible participants were interviewed as were 118 of 125 informants. The relationship between suicidal thinking & both cognitive impairment & depression was studied. 9 people showed suicidal thinking – all […]

Suicidality and Aggressive Behaviour in Alzheimer Patients: a Study Based on an Interview to Caregivers

Published in “The Suicidal Process: Challenges for Treatment and Prevention”

Suicide and Alzheimer Disease

Suicide and Alzheimer’s Pathology in the Elderly: a Case-control Study

Mental Health of the Ageing Immigrant Population


The Specificity of Depressive Symptoms in Patients With Alzheimer’s Disease

This study assessed the specificity of depressive symptoms in patients with Alzheimer’s disease & examined the discrepancies between patient & caregiver symptom reports. When compared to depressed patients without dementia, depressed patients with Alzheimer’s disease demonstrated a significantly higher score for suicide on the Hamilton depression scale. The implications of findings regarding depression levels in […]