The associations of cumulative adverse childhood experiences and irritability with mental disorders in detained male adolescent offenders

Background Adverse childhood experiences (ACEs) and psychiatric disorders are common in juvenile detainees. Emotional dysregulation resulting from cumulated ACEs may be characterized by symptoms of irritability. The present study examined whether the accumulation of ACEs, irritability, or both predicted mental disorders in incarcerated adolescents with and without controlling for one another and for socio-demographic factors. […]

Dysregulation and suicide in children and adolescents

Emotional and behavioral dysregulation have been associated consistently with suicidal behaviors across diagnostic groups and are independent risk factors acutely and chronically. Interventions for suicidal youth should focus on dysregulation using evidence-based psychotherapies as well as treating the underlying psychiatric disorder pharmacologically. Instruments are available to measure dysregulation across diagnostic groups and can be used […]

Religiousness and depressive symptoms in Europeans: Findings from the Survey of Health, Ageing, and Retirement in Europe

Objective:¬†Religiousness has been found to protect against depression based on studies conducted in the United States, though there are limited data in the European population. We sought to evaluate the associations between religiousness and six depressive symptoms in Europeans aged 50+ years. Study design:¬†Longitudinal study. Methods:¬†Our sample consisted of participants (n = 23,864) in wave […]

Pathways of association between childhood irritability and adolescent suicidality

OBJECTIVE: Childhood irritability predicts suicidal ideation/attempt (suicidality), but it is unclear whether irritability is an independent and direct risk factor for suicidality or a marker of intermediate mental health symptoms associated with suicidality. This study aimed to identify developmental patterns of childhood irritability and to test whether childhood irritability is directly associated with suicidality or […]

Animal models of suicide trait-related behaviors

Although antidepressants are at least moderately effective in treating major depressive disorder (MDD), concerns have arisen that selective serotonin reuptake inhibitors (SSRIs) are associated with suicidal thinking and behavior, especially in children, adolescents, and young adults. Virtually no experimental research in model systems has considered the mechanisms by which SSRIs may be associated with this […]

Association of childhood irritability and depressive/anxious mood profiles with adolescent suicidal ideation and attempts.

IMPORTANCE: Suicidal ideation and suicide attempt (suicidality) are common in adolescence and a public health concern. Childhood depression is a key risk factor for later suicidality and often co-occurs with irritability. No study to date has examined the joint association of depressive mood and irritability during childhood with later suicidality. OBJECTIVE: To investigate the association […]