Role of inflammation in suicide: From mechanisms to treatment

Suicidal behavior is complex and manifests because of a confluence of diverse factors. One such factor involves dysregulation of the immune system, which has been linked to the pathophysiology of suicidal behavior. This review will provide a brief description of suicidality and discuss the contribution of upstream and downstream factors in the etiology of suicidal […]

The role of inflammation in suicidal behaviour

Objective Over the past decade, clinical data have accumulated showing that inflammation might contribute to the pathophysiology of suicide. To evaluate the associations and to identify the support for pathways linking inflammatory processes with suicidal behaviour, a comprehensive review of the literature was undertaken. Method The search terms ‘cytokine’, ‘risk factors’, ‘kynurenine’, ‘asthma’, ‘allergy’, ‘autoimmunity’, […]

Can suicide behavior and seasonality of suicide be predicted from inflammatory parameters in adolescents?

According to the 2017 data of World Health organization approximately 800 million individuals commit suicide annually. After understanding that psychiatric  disorders start the inflammation process by suppressing the brain, a number of studies using neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and  monocyte/lymphocyte ratio have been conducted. Platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio and other hemogram parameters may […]

Role of inflammation in suicide: From mechanisms to treatment

Suicidal behavior is complex and manifests because of a confluence of diverse factors. One such factor involves dysregulation of the immune system, which has been linked to the pathophysiology of suicidal behavior. This review will provide a brief description of suicidality and discuss the contribution of upstream and downstream factors in the etiology of suicidal […]