Zolpidem as a high risk factor for elderly suicide in South Korea

Backgrounds South Korea, a nation with rapidly aging population, has the highest suicide rates in the world, and the elderly have a suicide rate three times higher than the national average. We classified the drugs ingested for suicide attempts by age groups and compare the clinical outcomes between non-elderly and elderly patients who attempted suicide […]

Zolpidem use and suicide death in South Korea: A population-based case-control study

Objective To investigate whether zolpidem use is associated with suicide death in adults. Method We conducted a case–control study using the National Health Insurance Service‐National Sample Cohort (NHIS‐NSC) database. Cases were adults with a suicide record (ICD‐10 codes; X‐60‐X84, Y87.0) between January 1, 2004 and December 31, 2013. 10 Controls were matched to each case […]

Insomnia and hypnotic medications are associated with suicidal ideation in a community population.

Suicidal ideation (SI), a significant predictor of suicide, is associated with sleep disturbance, which is seldom assessed using stringent diagnostic criteria and validated sleep instruments in community samples. Cross-sectional data, including sleep diaries and validated instruments, from 767 community adults were used to identify variables associated with SI and subsequently entered into a regression model […]

Are Sedatives and Hypnotics Associated With Increased Suicide Risk of Suicide in the Elderly?

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Suicide Among Drug Addicts in the UK

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Antidepressants and Benzodiazepines in the Treatment of Recurrent Suicidal Behaviour

Published in “The Suicidal Process: Challenges for Treatment and Prevention”

Drug Overdosage due to Glutethimide: a Reappraisal of Management

A case of severe overdosage with glutethimide successfully managed in the Respiratory Care Unit is presented. Certain important principles in management are illustrated & discussed. The authors emphasize the hazards of prescribing Doriden, especially to the patient predisposed to suicide. They suggest expectant treatment standing ready to offer ventilatory support as the need arises. (12 […]

Triazolam Blood Concentrations in Forensic Cases in Canada

The object of this report is to present blood concentrations of triazolam as found in forensic cases in Canada, including 4 cases of suicide. (28 refs)

Midazolam and the Treatment of Catatonia in Major Depression in an Older Adult

The case of a 74-year-old male who presented with symptoms of catatonia is reported. These symptoms responded to midazolam, a benzodiazepine. Midazolam was administered as a preprocedural sedative – in this period the subject was able to describe his symptoms of dysphoria, including suicidal ideation. After starting treatment with lorazepam & nortriptyline, the patient showed […]

Regular Hypnotic Drug Treatment in a Sample of 32,679 Swedes: Associations with Somatic and Mental Health, Inpatient Psychiatric Diagnoses and Suicide, Derived With Automated Record-Linkage

In this study, people who reported regular treatment with hypnotic drugs were tested in order to find associations with perceived health problems, inpatient psychiatric diagnoses, & subsequent suicides. The authors found that there was substantial concurrent psychoactive drug treatments, nervous symptoms & insomnia, as well as high rates of circulatory & musculoskeletal conditions. Also, the […]

Psychopathology and Treatment of 30,344 Twins in Sweden. I. The Appropriateness of Psychoactive Drug Treatment

This study examines whether regular treatment with tranquilizing & hypnotic drugs among 30,344 twins in Seden 15-47 years old was associated with poor health. The authors found a substantial relationship between psychopathology, somatic health problems, suicide, & reported treatment with psychoacitve medication. The authors also found women were almost twice as likely to report medication […]

A Fatal Case Involving Hydroxyzine

Presents the case history of a 43-year-old woman who died from a self-inflicted overdose of hydroxyzine. Gas chromatography was used to analyze the drug which was extracted from blood & other tissues. Tissue concentrations are included. 7 refs.

Role of Drugs in Suicide

Dr. Frank Berger reports that barbiturates are most frequently used in suicide attempts (1966). The use of tranquilizers has not decreased the use of barbiturates for suicidal purposes. Four tables list numbers of suicides by specific causes, by type of drug overdose, by analgesic & soporific substances, & by analgesics & soporific substances.

Hemodialysis for Methyprylon (Noludar) Poisoning

The authors present a case of methyprylon (No ludar) overdose treated with extracorporeal hemodialysis. Dramatic clinical improvement was shown during the 9 hour period of dialysis with serum methyprylon levels decreasing from 4 to 0.4 mg/ml. Less than 10% of the ingested methyprylon was recovered from the bath. Dialysis of the toxic metabolites of the […]

Self-Poisoning With “Mandrax”

Twelve cases of “mandrax” overdose (7 females, 5 males) are described. Symptomatology included hyperflexia, hypertonia, clonus, muscle twitching, & lowered body temperature. Biomedical treatment is discussed.

Acute Overdosage of Hypnotic-Sedative-Tranquilizer Drugs with Special Reference to Glutethimide

The general priciples of intensive conservative treatment are reviewed for acute intoxication with drugs having marked central depressed action in overdose, whether or not said drugs are barbituric acid such as hemodialysis are then discussed with special reference to glutethimide intoxication, emphasizing the relationship of therapeutic procedures of this sort to the well-defined patterns of […]

A 4-6-Year Follow-Up of 50 Patients With Primary Dependence on Sedative & Hypnotic Drugs

The authors studied 50 of 55 patients orginally hospitalized for primary sedative-hypnotic dependence 4-6 years after hospital discharge. 42 (84%) had resumed use, 26 (52%) were abusing drugs at follow-up & 21 (42%) had been readmitted for drug abuse. 3 patients experienced delirious states & 6 experienced epileptic seizures associated with withdrawal. Physical signs of […]

The Abuse of Hypnotics

Changing Pattern of Drugs Used for Self Poisoning

The changes in pattern of drug use in self-poisoning were reviewed & their consequences assessed. Benzodiazepines increased markedly to 40% of patients admitted while barbituates declined from 30% to 15%. Tricyclic antidepressants saw a slow increase. The pattern showed a reduction in number & severity of patients admitted unconscious, in proportional terms. However, there is […]

Spontaneous Recovery From Gross Suicidal Overdoseage With Methylpentynol (Methyl-Parafynol)

Self-Poisoning With Barbiturates in England and Wales During 1959-74

Hospital admissions due to acute barbiturate poisoning per million population in England and Wales have decreased since 1965 at about the same rate as NHS prescriptions for barbiturates. Admissions due to poisoning with other drugs have increased, but, largely because the benzodiazepine hypnotics and tranquilizers are much less toxic than the barbiturates that they are […]

Self Poisoning With Drugs: a View From a General Medical Unit

Pattern of Acute Drug Poisoning in Oslo