Resource Tag: HYPNOTICS

Backgrounds South Korea, a nation with rapidly aging population, has the highest suicide rates in the world, and the elderly have a suicide rate three times higher than the national average. We classified the drugs ingested for suicide attempts by age groups and compare the clinical outcomes between non-elderly and elderly patients who attempted suicide […]

Objective To investigate whether zolpidem use is associated with suicide death in adults. Method We conducted a case–control study using the National Health Insurance Service‐National Sample Cohort (NHIS‐NSC) database. Cases were adults with a suicide record (ICD‐10 codes; X‐60‐X84, Y87.0) between January 1, 2004 and December 31, 2013. 10 Controls were matched to each case […]

Suicidal ideation (SI), a significant predictor of suicide, is associated with sleep disturbance, which is seldom assessed using stringent diagnostic criteria and validated sleep instruments in community samples. Cross-sectional data, including sleep diaries and validated instruments, from 767 community adults were used to identify variables associated with SI and subsequently entered into a regression model […]

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Published in “The Suicidal Process: Challenges for Treatment and Prevention”

A case of severe overdosage with glutethimide successfully managed in the Respiratory Care Unit is presented. Certain important principles in management are illustrated & discussed. The authors emphasize the hazards of prescribing Doriden, especially to the patient predisposed to suicide. They suggest expectant treatment standing ready to offer ventilatory support as the need arises. (12 […]

The object of this report is to present blood concentrations of triazolam as found in forensic cases in Canada, including 4 cases of suicide. (28 refs)

The case of a 74-year-old male who presented with symptoms of catatonia is reported. These symptoms responded to midazolam, a benzodiazepine. Midazolam was administered as a preprocedural sedative – in this period the subject was able to describe his symptoms of dysphoria, including suicidal ideation. After starting treatment with lorazepam & nortriptyline, the patient showed […]

In this study, people who reported regular treatment with hypnotic drugs were tested in order to find associations with perceived health problems, inpatient psychiatric diagnoses, & subsequent suicides. The authors found that there was substantial concurrent psychoactive drug treatments, nervous symptoms & insomnia, as well as high rates of circulatory & musculoskeletal conditions. Also, the […]

This study examines whether regular treatment with tranquilizing & hypnotic drugs among 30,344 twins in Seden 15-47 years old was associated with poor health. The authors found a substantial relationship between psychopathology, somatic health problems, suicide, & reported treatment with psychoacitve medication. The authors also found women were almost twice as likely to report medication […]

Presents the case history of a 43-year-old woman who died from a self-inflicted overdose of hydroxyzine. Gas chromatography was used to analyze the drug which was extracted from blood & other tissues. Tissue concentrations are included. 7 refs.

Dr. Frank Berger reports that barbiturates are most frequently used in suicide attempts (1966). The use of tranquilizers has not decreased the use of barbiturates for suicidal purposes. Four tables list numbers of suicides by specific causes, by type of drug overdose, by analgesic & soporific substances, & by analgesics & soporific substances.

The authors present a case of methyprylon (No ludar) overdose treated with extracorporeal hemodialysis. Dramatic clinical improvement was shown during the 9 hour period of dialysis with serum methyprylon levels decreasing from 4 to 0.4 mg/ml. Less than 10% of the ingested methyprylon was recovered from the bath. Dialysis of the toxic metabolites of the […]

Twelve cases of “mandrax” overdose (7 females, 5 males) are described. Symptomatology included hyperflexia, hypertonia, clonus, muscle twitching, & lowered body temperature. Biomedical treatment is discussed.

The general priciples of intensive conservative treatment are reviewed for acute intoxication with drugs having marked central depressed action in overdose, whether or not said drugs are barbituric acid such as hemodialysis are then discussed with special reference to glutethimide intoxication, emphasizing the relationship of therapeutic procedures of this sort to the well-defined patterns of […]

The authors studied 50 of 55 patients orginally hospitalized for primary sedative-hypnotic dependence 4-6 years after hospital discharge. 42 (84%) had resumed use, 26 (52%) were abusing drugs at follow-up & 21 (42%) had been readmitted for drug abuse. 3 patients experienced delirious states & 6 experienced epileptic seizures associated with withdrawal. Physical signs of […]

Hospital admissions due to acute barbiturate poisoning per million population in England and Wales have decreased since 1965 at about the same rate as NHS prescriptions for barbiturates. Admissions due to poisoning with other drugs have increased, but, largely because the benzodiazepine hypnotics and tranquilizers are much less toxic than the barbiturates that they are […]

A case is described in which a 55 year old man committed suicide by taking nitrazepam (Mogadon) and alcohol. Chronic bronchitis was considered to be a major contributory factor. Toxicological data are given.