Association between serum cholesterol and depression, aggression and suicidal ideation in war veterans with posttraumatic stress disorder: A cross-sectional study.


Is it valid to measure suicidal ideation by depression rating scales?


Transdermal Selegiline in Major Depression: a Double-Blind, Placebo-Controlled, Parallel-Group Study in Outpatients


Sleep Disorder, Depression, and Suicidality in Female Sexual Assault Survivors

As an exploratory, hypothesis-generating study, 153 female sexual assault survivors with posttraumatic stress disorder who had enrolled in a nightmare treatment program were assessed for subjectively determined sleep breathing & sleep movement disorders. Potential sleep breathing & sleep movement disorders were present in 80% of the participants. Based on the Hamilton Depression Rating Scale & […]

Antidepressants: Partial Response in Chronic Depression

This article reviews the literature on the clinical implications of a partial response to use of antidepressants in depression treatment. Patients who fail to reach premorbid levels of symptom remission are more vulnerable to relapse, work impairment, & suicide. Partial response may be one form of treatment resistance. Up to 20% of patients with major […]

Urinary Catecholamines and Cortisol in Parasuicide

This article describes a study of 42 patients tested within 24 hours of admission to an Ontario hospital. Suicide attempters has significantly higher norepinephrine than did control patients with suicide ideation. In contrast, urinary dopamine, epinephrine, the NE/EPI ratio, urinary free cortisol, & serum cortisol did not differ between groups. Data is provided for 4 […]

Features Associated With Suicide Attempts in Depression: a Partial Replication

The study reported in this article examined clinical & sympotomatic features in a heterogenous group of 44 depressed patients. Those who had attempted suicide: had their 1st episode of affective disorder at a significantly earlier age; had more episodes of affective disorder; & more of them had bipolar disorder. A family history of suicide was […]

Thyrotropin Response to Thyrotropin-Releasing Hormone in Patients With Dementia of the Alzheimer Type

11 patients with senile dementia of the Alzheimer type & 11 age-matched control subjects were given the thyrotropin-releasing hormone test. There were significant differences between the groups on Hamilton Depression Rating Scale scores, although neither group met clinical criteria for depression. Items that were significantly different pertained to depressed mood, loss of interest, loss of […]

Cerebrospinal Fluid Monoamine Metabolites and Suicidal Behavior in Depressed Patients: a 5-Year Follow-up Study

A 5-year follow-up study of suicidal behavior among depressed patients who earlier had determinations of cerebrospinal fluid (CSF) levels of monoamine metabolites. Reattempters, especially melancholic patients, had significantly lower CSF levels of the serotonin metabolite 5-hydroxyindoleacetic acid & dopamine metabolite homovanillic acid. Thus reduced CSF levels may be related to further suicidal behavior among depressed […]

Repeat Self-Harm: and 18-Month Follow-up

An 18-month follow-up of cases of deliberate self-harm (DSH) revealed that 30% had repeated the act. Of a large number of times recorded at index DSH, only one, a past history of self-harm, was associated with repetition. It is suggested that some factors not predictive of longer term repeat DSH may be important in the […]

The Dexamethasone Suppression Test and Suicide Attempts

The authors examinedcovariations between results of the dexamthasone suppression test (DST) & suicidal behavior for 44 attempted suicide patients. The suicide methods, diagnoses & time factors were controlled for. Despite hypotheses suggesting the contrary, no significant relationship between DST results & suicide attempts was found. Sensitivity of DST with suicide attempts was 52% in patients […]

Assessment of Suicide Risk by Computer-Delivered Self-Rating Questionnaire: Preliminary Findings

102 patients admitted to a hospital after an episode of deliberate self-harm were interviewed by a computer & then by a psychiatrist. The computer interview consisted of a self-rating modification of the Hamilton Rating Scale for Depression & a self-rating questionnaire for suicidal ideation. There was a significant pathoplastic effect of the personality of the […]

Short-term Course of Depression Following Attempted Suicide: a Preliminary Report

This article reports on the course of depression over 1 week in 265 patients hospitalized following a suicide attempt. They were examined using a clinical interview, depression questionnaire, & 2 depression rating scales. On all measures the group had depression of moderate to marked severity at time of suicide attempt. In males & younger patients […]

Single-Sign Rorschach Suicide Indicators: a Validity Study Using a Depressed Inpatient Population

This study tests the validity of using single responses on the Rorschach as a indicators of current suicidal risk. Applebaum & Holzman’s (1962) color-shading sign was found to be related to low suicidal risk. Blatt & Ritzler’s (1974) transparency sign was found to be unrelated to current suicide risk but still related to a past […]

A Comparative Clinical Trial of Fluoxetine, Mianserin and Placebo in Depressed Outpatients

This study compared fluoxetine with mianserin & placebo in 52 depressed outpatients. Findings included: significantly more patients on fluoxetine improved than those on placebo; for mianserin, no significant differences were found with either fluoxetine & placebo; suicidal feelings were reduced to a greater degree on fluoxetine than on mianserin & placebo; fluoxetine induced weight loss, […]

Serotonergic Studies in Patients With Affective and Personality Disorders

Dysfunction of the central serotonergic system has been associated with depression & with suicidal &/or impulsive aggressive behavior. Prolactin responses to a challenge with fenfluramine hydrochloride were examined in 45 male patients with major affective &/or personality disorder. Results suggest that reduced central serotonergic function is present in a subgroup of patients with major affective […]

Cognitive Predictors of Depression & Suicide Ideation

The intensity of depressive symptomatology, lethality of current suicide ideation, & cognitive variables presumed to mediate depression & suicidality were measured for 136 adults with major depression. Findings: depressive symptomatology was best predictd by Beck’s Hopelessness Scale in combination with the detachment factor of the Crandell Cognitions Inventory; & suicidality, by the selective abstraction & […]

Deliberate Self Harm-Correlates of Suicidal Intent and Severity of Depression

In a study of 98 cases of deliberate self harm, a high correlation was obtained between a diagnosis of major depressive disorder (MDD) & scores on both the Hamilton rating for depression (HRS) & the suicide intent scale (SIS). There was also a high correlation between HRS and SIS scores. A higher score on HRS […]

Use of the Children’s Depression Rating Scale in an Inpatient Psychiatric Population

The Children’s Rating Scale is a useful & reliable instrument for measuring the severity of depression in children. The scale was initialy used in pediatric liaison population. This study reports its use in consecutive admissions to a child inpatient unit. Systematic evaluations of the children resulted in many diagnosis of depression which were missed by […]

Distal Colon Motility and Clinical Parameters in Depression

Depression Factors in Depressed and on Heterogeneous In-Patient Samples

Losses, Hostility, and Depression

Forty depressed patients were compared to 40 matched control subjects in terms of hostility, depression and life events. More hostility was seen in the patients, and correlations between hostility and depression symptoms are reported. The number of loss life events was not related to hostility, but patients with no losses had a higher correlation between […]

Role of Past Loss in Depression