The effect of the Yara smartphone application on anxiety, sleep quality, and suicidal thoughts in patients with major depressive disorder in Iran: A randomized controlled trial

Background Depression is one of the most common mental disorders that leads to anxiety, sleep disturbances, and suicidal thoughts. Due to the high cost of treatment and the reluctance of many patients to seek medical help, major depressive disorder (MDD) is becoming more prevalent. Therefore, alternative methods like smartphone applications can help prevent and improve […]

The residential, area-specific prevalence and associated factors of suicidal ideation among South Korean adolescents

Objectives: This study investigated the residential, area-specific prevalence and associated factors of suicidal ideation among adolescents in South Korea, based on nationally representative data. Methods: A secondary analysis was performed using the database of the 17th Korean Youth Health Behavior Survey, which contained data from 54,848 adolescents. Results: Female adolescents (more influential in counties), low […]

Examining suicide risk in sexual and gender minority youth: A descriptive observational study on depressive symptoms, social support and self-esteem

Aim: To understand the factors that contribute to the risk of suicide among lesbian, gay, bisexual, transgender, queer, intersex and asexual (sexual minorities) youth. Background: The increase in the likelihood of suicide has made it an urgent issue in public health, particularly among young people, where it now ranks as the fourth leading cause of death. This […]

Dataset on the effects of psychological care on depression and suicide ideation in underrepresented children

Massive increases in the risks of depressive disorders and the ensuing suicide have become the overarching menace for children/adolescents. Despite global consensus to instigate psychological healthcare policy for these children/adolescents, their effects remain largely unclear neither from a small amount of official data nor from small-scale scientific studies. More importantly, in underprivileged children/adolescents in lower-middle-economic-status […]

Depression, complicated grief, and suicide ideation following bereavement during the COVID-19 pandemic

Many people lost a relative during the COVID-19 pandemic. Such a loss may have deleterious implications due to the circumstances of bereavement during lockdowns and social distancing. This study aimed to explore depressive symptoms, complicated grief, and suicidal ideation in the grieving process among 104 bereaved jewish adults who had lost relatives during the COVID-19 […]

Integrative analyses of scRNA-seq, bulk mRNA-seq, and DNA methylation profiling in depressed suicide brain tissues

Background Suicidal behaviors have become a serious public health concern globally due to the economic and human cost of suicidal behavior to individuals, families, communities, and society. However, the underlying etiology and biological mechanism of suicidal behavior remains poorly understood. Methods We collected different single omic data, including single-cell RNA sequencing (scRNA-seq), bulk mRNA-seq, DNA […]

Remaining between the cracks: The long-term effect of different suicide risk exclusion criterion on outcomes of an online intervention for depression

Background: Previous studies have demonstrated that excluding individuals at risk of suicide from online depression interventions can impact recruited sample characteristics. Aim: To determine if a small change in suicide risk exclusion criterion led to differences in the usage and effectiveness of an Internet depression intervention at 6 months of follow-up. Method: A partial sample of a recently completed online […]

Suicide attempts and depression associated factors among the male child sexual abuse survivors in Bangladesh

In Bangladesh, male child sexual assault is seldom ever reported. Due to cultural standards, sexual assault survivors often refrain from talking about their experiences. Depression therefore overtakes them. Their mental health declines and their chance of committing suicide rises. The goal of this study was to explore depression and suicide attempts among Bangladeshi male child sexual […]

Grey matter abnormalities in major depressive disorder patients with suicide attempts: A systematic review of age-specific differences

Background Previous studies have reported alterations in brain structure in major depressive disorder (MDD) patients with suicide attempts. However, age-related changes in suicidal MDD patients remain unclear. Methods We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, PubMed, and Web of Science were searched to identify […]

Relationship between biological rhythm dysregulation and suicidal ideation in patients with major depressive disorder

Background Although the disturbance of circadian rhythms represents a significant clinical feature of major depressive disorder (MDD), the relationship between biological rhythm disturbances and the severity of suicidal ideation in individuals with MDD remains unclear. We aimed to explore the characteristics of different biological rhythm dimensions in MDD and their association with the severity of […]

Prevalence and correlates of severe anxiety in patients with first hospitalization for major depressive disorder combined with dyslipidemia: A large sample cross-sectional study

Background: Anxiety symptoms and dyslipidemia are common co-morbidities in patients with major depressive disorder (MDD), and there are complex pathophysiologic as well as clinical mechanisms underlying the association between the three. In this study, we investigated the prevalence and associated factors of severe anxiety in first-time hospitalized patients with MDD with dyslipidemia. Methods: We included 708 patients […]

Gender differences in prevalence and associations between cognitive symptoms and suicidal ideation in patients with recurrent major depressive disorder: Findings from the Chinese NSSD study

Background This study aimed to explore gender differences in associations between cognitive symptoms and suicidal ideation (SI) among patients with recurrent major depressive disorder (MDD). Methods We recruited 1222 patients with recurrent MDD from the National Survey on Symptomatology of Depression (NSSD), a survey designed to investigate the symptoms experienced during current major depressive episodes […]

Distinct correlation network of clinical characteristics in suicide attempters having adolescent major depressive disorder with non-suicidal self-injury

Suicidal behavior and non-suicidal self-injury (NSSI) are common in adolescent patients with major depressive disorder (MDD). Thus, delineating the unique characteristics of suicide attempters having adolescent MDD with NSSI is important for suicide prediction in the clinical setting. Here, we performed psychological and biochemical assessments of 130 youths having MDD with NSSI. Participants were divided […]

Clinical utility of depression measures and symptoms: Implications for suicide risk assessment in high risk, resource limited youth populations

Objective Suicide risk for youth in resource- limited settings has been largely underrepresented in the literature and requires targeted examination of practical ways to address this growing public health concern. The present study focuses on the clinical utility of depression risk assessment tools addressing how and for whom suicide prevention intervention is most beneficial within […]

The effect of parent–adolescent discrepancies in reports of familial dysfunction and depression on suicidal ideation in adolescents

Introduction Parents and adolescents are often discrepant in their reports of adolescent psychosocial factors. Few studies have addressed parent–adolescent discrepancies in subjective ratings of familial dysfunction and depression as longitudinal predictor variables, and none have done so in a treatment setting for adolescents with acute suicidality. This study examined how parent–adolescent discrepancies in familial dysfunction […]

Efficacy of mentalization-based therapy in treating self-harm: A systematic review and meta-analysis

Introduction Mentalization-based therapy (MBT) and its adapted version for adolescents (MBT-A) are repeatedly highlighted as promising treatments for reducing self-harm, particularly in borderline personality disorder (BPD). Despite the availability of publications providing evidence of their efficacy in reducing self-harm, recent meta-analyses have yielded mixed results. To inform best-practice clinical decision-making, we conducted a systematic review […]

Firearm carrying and adolescent suicide risk outcomes between 2015 and 2021 across nationally representative samples

Introduction Firearms are the most frequent means of youth suicide for the 14–18-year-old age group, and adolescent firearm access confers substantial increases in the risk of suicidal behaviors. There have been significant increases in firearm purchases and firearm violence in the United States since the onset of the COVID-19 pandemic. Methods This study uses four […]

Perinatal depression and risk of mortality: Nationwide, register based study in Sweden

Objective To determine whether women with perinatal depression are at an increased risk of death compared with women who did not develop the disorder, and compared with full sisters. Design Nationwide, register based study. Setting Swedish national registers, 1 January 2001 to 31 December 2018. Participants 86 551 women with a first ever diagnosis of perinatal depression ascertained through specialised […]

The mental health of Canadian transgender youth compared with the Canadian population

Objectives—This study documents the prevalence of mental health concerns among Canadian transgender youth and makes comparisons with cisgender or mostly-cisgender population-based studies. This study also  compares gender identity subgroups (transgender girls/women, boys/men, and non-binary) and age subgroups (14–18 year olds and 19–25 year olds) on mental health outcomes. Methods—A nonprobability sample of 923 transgender youth […]

Variations in suicide risk and risk factors after hospitalization for depression in Finland, 1996-2017

Importance Although incidence of suicide in depression varies remarkably temporally, risk factors have been modeled as constant and remain uncharted in the short term. How effectively factors measured at one point in time predict risk at different time points is unknown. Objective To examine the absolute risk and risk factors for suicide in hospitalized patients […]

Emotional dysregulation in adolescents: Implications for the development of severe psychiatric

Well-tuned emotional regulation is fundamental for human life and psychological well-being. Negative physiological emotions are counterbalanced by positive ones, and this equilibrium is the mainstay of human physiological affective states. However, this mechanism may sometimes become dysfunctional when negative emotions are not correctly counterbalanced, causing maladaptive behaviors, especially during adolescence. A very interesting review by […]

Depression predicts emotion acceptance beliefs in early adolescence: A longitudinal investigation

Objectives Adolescence is a time period which confers significant risk for the development of psychopathology. There is increasing consensus within the literature that beliefs about one’s emotional experience are important and may present a unique risk factor during this time period. However, to date, there has been no longitudinal examination of the relationship between depression […]

Attachment-based family therapy for adolescents and young adults with suicide ideation and depression: An open trial

Background: Suicide ideation among adolescents is difficult to treat. Attachment-based family therapy (ABFT) is a promising evidence-based family intervention developed to decrease depressive symptoms and suicide ideation among adolescents. Aims: This open trial assessed the feasibility of ABFT for adolescents (12–23 years) with suicide ideation and depression in an outpatient community mental health center in […]