Syndemic relationship of depressive symptoms, substance use, and suicidality in transgender youth: A cross‑sectional study using the U.S. youth risk behavior surveillance system

Purpose Syndemics are co-occurring epidemics that cluster within populations due to shared socio-structural factors and are often in populations with intersecting forms of vulnerability. Suicide, depression, and substance use all disproportionately affect transgender and gender diverse (TGD) youth. In this study, we test a syndemic model of the relationship between these three mental health conditions […]

The association among serum growth differentiation factor 15 level and suicidal ideation is dependent on testosterone deficiency in depressive patients

Background: Elevated levels of growth differentiation factor (GDF)-15 and reduced levels of testosterone have been linked to depressive disorder, but whether they are also linked to suicidal ideation in patients with depression is unclear. Methods: This retrospective study involved 301 patients ≥ 22 years old hospitalized for depression between July 2018 and November 2020 at Renmin Hospital […]

Teen depression and suicide prevention: Standard treatment guidelines 2022

Suicide is the third leading cause of adolescent mortality in India and the fifth leading cause, globally. Every hour one child dies of suicide in India. Most adolescent suicides are impulsive. They commit suicide mainly by hanging, poisoning, drowning, and self-immolation. The important causes are family problems, break-up in romantic relationships, physical and mental illness, […]

Moderation effects of coping flexibility on the association between depressive symptoms and suicidal risk

Background: This study focused on poor coping flexibility, which involves the perseveration of a failed coping strategy, as a moderator of the association between depression and suicidal risk; no study has previously examined the association between coping flexibility and suicidal risk. Aims: This study examined whether individuals with lower coping flexibility would have a stronger suicidal risk when […]

Epidemiology of suicide and suicide attempts in Jahrom district, Southern Iran in light of COVID pandemic: A prospective observational study

Background and Aims Suicide is a global public health issue. The covid-19 epidemic has led to disturbance in daily life and economic activity. It is assumed that increased stress and anxiety cause suicide. This study aimed to describe the causes and methods of committing suicide during the COVID pandemic. Methods This descriptive study was conducted on […]

Classical psychedelics for the treatment of depression and anxiety: A systematic review

Background: Depression and anxiety are prevalent psychiatric disorders that carry significant morbidity. Pharmacological and psychosocial interventions are used to manage these conditions, but their efficacy is limited. Recent interest into the use of psychedelic-assisted therapy using ayahuasca, psilocybin or lysergic acid diethylamide (LSD) may be a promising alternative for patients unresponsive to traditional treatments. This review […]

The serotonin theory of depression: A systematic umbrella review of the evidence

The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. PubMed, EMBASE and PsycINFO were searched using terms appropriate to each area of research, from their inception […]

Single-dose psilocybin for a treatment-resistant episode of major depression

BACKGROUND Psilocybin is being studied for use in treatment-resistant depression. METHODS In this phase 2 double-blind trial, we randomly assigned adults with treatment resistant depression to receive a single dose of a proprietary, synthetic formulation of psilocybin at a dose  of 25 mg, 10 mg, or 1 mg (control), along with psychological support. The primary […]

Mental health services use and depressive symptom scores among gay and bisexual men in Canada

Purpose To evaluate the association between mental health services (MHS) use and depressive symptom scores among gay and bisexual men (GBM) and compare with heterosexual men in Canada. Methods We used data from the 2015–2016 cycles of the Canadian Community Health Survey. Depressive symptoms were assessed using the PHQ-9 questionnaire (prior two weeks). MHS consultations […]

Cognitive effort avoidance in veterans with suicide attempt histories

Suicide attempts (SA) are increasing in the United States, especially in veterans. Discovering individual cognitive features of the subset of suicide ideators who attempt suicide is critical. Cognitive theories attribute SA to facile schema-based negative interpretations of environmental events. Over-general autobiographical memory and facile solutions in problem solving tasks in SA survivors suggest that aversion […]

Association of prior depressive symptoms and suicide attempts with subsequent victimization: Analysis of population-based data from the Adult Psychiatric Morbidity Survey

Background: Symptoms of mental disorder, particularly schizophrenia, predispose to victimization. Much less is known about the relationship between depressive symptoms and later victimization in the general population, the influence of these symptoms on types of subsequent victimization, or the role of symptom severity. We investigated this in nationally representative data from the United Kingdom. Methods: […]

Can cognition help predict suicide risk in patients with major depressive disorder? A machine learning study

Background Previous studies suggest that deficits in cognition may increase the risk of suicide. Our study aims to develop a machine learning (ML) algorithm-based suicide risk prediction model using cognition in patients with major depressive disorder (MDD). Methods Participants comprised 52 depressed suicide attempters (DSA) and 61 depressed non-suicide attempters (DNS), and 98 healthy controls […]

Parental psychological control, parent-related loneliness, depressive symptoms, and regulatory emotional self-efficacy: A moderated serial mediation model of nonsuicidal self-injury

Objective Adolescent nonsuicidal self-injury (NSSI) has become an alarming public health concern. Parental psychological control has been identified as a risk factor for NSSI in some western samples. However, the relationship between parental psychological control and NSSI remains unclear among Chinese adolescents. Furthermore, little is known about how parental psychological control affects NSSI. This study […]

Inpatient suicides in late life: A retrospective analysis of a hospital group with nine psychiatric clinics

Objective Inpatient suicides are rare incidents; however, the impacts of such events on associated families and hospital staff are severe. Therefore, preventive strategies need to focus on risk factors. Clinical management in a hospital setting must integrate the home environment and social life of patients. Nevertheless, home leaves require careful preparation. Methods Suicides were reported […]

Suicidal behaviors in women with the hypermobile Ehlers-Danlos syndrome

Background Hypermobile Ehlers–Danlos syndrome (hEDS) is the most frequent heritable disorder of the connective tissue. This is characterized by a generalized fragility of tissues leading to chronic pain, disability and high levels of psychological distress. Suicidal behaviors in those affected are not uncommon but they have not been well studied. We aimed to explore aspects […]

The difference of suicidal ideation between shift workers and day workers by gender

Shift work does not synchronize with the 24-hour human circadian rhythm, so shift workers experience various problems related to this disruption. This study investigated the relationship between suicidal risk and emotional difficulties such as depression and anxiety in shift workers according to gender. We analyzed data collected from 79,009 health checkup recipients. We checked psychosocial […]

Changes after emergency assessment of suicidal patients: An unexpected outcome

Introduction Acute Suicide Risk (ASR) is widely evaluated at Emergency Departments (ED). Little is known about follow-up of ASR after psychiatric ED evaluation, and if there are differences within No ASR (NASR) counterparts at baseline and afterwards. Method We developed a naturalistic, 3-month follow-up study of adult patients from a psychiatric ED in Mexico City. […]

The specific roles of loss of interest and loss of pleasure in recent suicidal ideation

Background Evidence suggests that recent changes in anhedonia may be more predictive of suicidal ideation than either state or trait anhedonia alone. However, the individual role that anhedonia symptoms play in suicidality is not yet well established. Methods This study investigated whether state, trait, and recent changes in anhedonia predicted recent suicidal ideation, using cross-sectional […]

Latent toxoplasmosis is associated with depression and suicidal behavior

Objective Neuroinflammation is implicated in the pathophysiology of depression. Toxoplasma gondii (T. gondii) causes chronic brain inflammatory process and may thus contribute to both depression and its most serious complication, suicidal behavior. In this study, we hypothesized that latent toxoplasmosis may underlie current depression and/or suicidal behavior. Method Currently depressed individuals (N = 384) and age, sex, and residence-matched […]

Emotion regulation and depressive symptoms mediate the association between schizotypal personality traits and suicidality in Chinese college students

Objective The psychological mechanisms underlying the relationship between schizotypal personality traits and suicidality are not understood. This study investigated the association of schizotypal personality traits with suicidality and explored the mediating role of cognitive appraisal and depression in the relationship between those two variables in a sample of Chinese college students. Method Participants (N = 2457) completed […]

Implicit associations of nonsuicidal self-injury with relief in posttraumatic stress and depressive disorders

Although once considered a defining feature of borderline personality disorder, research has found high rates of NSSI among individuals with other psychiatric disorders, particularly posttraumatic stress disorder (PTSD) and depressive disorders. A recent study from our research team found that lifetime PTSD and depressive disorders were associated with unique self-reported NSSI motives. Given well-established limitations […]

Emotional abuse and perceived stress: The most relevant factors in suicide behavior in first-episode psychosis patients

People with a mental disorder have a higher risk of suicidal behavior. Little research has examined the role of childhood trauma in suicide behavior, and even fewer studies have assessed the specific relevance of subtypes of childhood trauma and suicidal behavior in first-episode psychosis (FEP). The aims of the present study were: 1) to compare […]

Pain catastrophizing as a predictor of suicidal ideation in chronic pain patients with an opiate prescription

Chronic pain and opioid use are associated with increased risk for suicidal ideation and behaviors (SIB) in cross-sectional studies, particularly among individuals who catastrophize about their pain. This study examined the longitudinal association between  two styles of pain coping, catastrophizing and hoping/praying, as predictors of subsequent SIB, as well as possible mediators of this association […]