Effectiveness of suicide prevention program (SPP) on knowledge, attitude and gatekeeper behaviour among teachers of selected Pre University colleges of Udupi district: A study protocol for randomized controlled trial

Objective: The study objective is to determine the effectiveness of the suicide prevention program (SPP) on knowledge, attitude, and gatekeeper behaviour among teachers of Pre University colleges. Method: This is a randomized controlled study, divided into two phases with assessments at baseline, one month, three months, and six months. A descriptive cross-sectional survey will be […]

Suicide prevention for substance using youth experiencing homelessness: Study protocol for a randomized controlled trial

Background While research on substance using youth experiencing homelessness (YEH) is increasing, there is a dearth of information regarding effective prevention interventions for these youth. Suicide is the leading cause of death among YEH and most youth do not access services that may be available to them. Therefore, this study seeks to address this gap […]

Mindfulness-based cognitive therapy for individuals who are suicidal: A randomized controlled trial

There is a need for well-described treatments targeting individuals at risk for suicidal behaviors. The present study aims to investigate the effectiveness of MBCT adapted to individuals who are suicidal (MBCT-S) in a randomized controlled trial, comparing an intervention group receiving MBCT-S and treatment as usual (TAU) with a control group receiving TAU only. Participants […]

Wakȟáŋyeža (Little Holy One) – an intergenerational intervention for Native American parents and children: A protocol for a randomized controlled trial with embedded single-case experimental design

Background Trauma within Native American communities compromises parents’ parenting capacity; thus, increasing childrens’ risk for substance use and suicide over the lifespan. The objective of this manuscript is to describe the Wakȟáŋyeža (Little Holy One) intervention and evaluation protocol, that is designed to break cycles of intergenerational trauma, suicide, and substance use among Fort Peck […]

Randomized controlled trial of an online suicide prevention gatekeeper training program: Impacts on college student knowledge, gatekeeper skills, and suicide stigma

Background: Suicide prevention gatekeeper training programs offer a unique opportunity to increase knowledge about suicide prevention, enhance risk identification, and reduce suicide-related stigma. Aims: This study evaluated the efficacy of an online suicide prevention gatekeeper training program in a randomized trial. Method: Participants were US college students (N = 388). Participants (69.3% women) had a mean […]

Engaging Black youth in depression and suicide prevention treatment within urban schools: Study protocol for a randomized controlled pilot

Background: Depression continues to be an ongoing threat to adolescent well-being with Black adolescents being particularly vulnerable to greater burdens of depression as well as lower mental health service utilization. Black adolescents are likely to have untreated depression due to social network influences, varied perceptions of services and providers, or self-stigma associated with experiencing depressive symptoms. […]

Brief video training for suicide prevention in veterans: A randomized controlled trial of VA S.A.V.E.

Introduction VA S.A.V.E. (Signs; Ask; Validate; Encourage/Expedite) is a gatekeeper training developed by the Department of Veterans Affairs (VA) that teaches individuals to identify and assist veterans at risk for suicide. Although VA S.A.V.E. has been widely disseminated, rigorous evaluation is lacking. Methods In a pilot randomized controlled trial of a brief, video-based version of […]

Wakȟáŋyeža (Little Holy One): An intergenerational intervention for Native American parents and children: a protocol for a randomized controlled trial with embedded single-case experimental design

Background Trauma within Native American communities compromises parents’ parenting capacity; thus, increasing childrens’ risk for substance use and suicide over the lifespan. The objective of this manuscript is to describe the Wakȟáŋyeža (Little Holy One) intervention and evaluation protocol, that is designed to break cycles of intergenerational trauma, suicide, and substance use among Fort Peck […]

Group brief cognitive behavioral therapy for suicide prevention compared to dialectal behavior therapy skills group for military service members: A study protocol of a randomized controlled trial

Background Suicide is a pressing matter for the military. Not only does it pose a health risk, but suicide also compromises operational readiness. Despite provision of suicide prevention clinical best practices, the Department of Defense suffers several challenges (e.g., clinician shortages) limiting the agency’s ability to effectively respond to service member suicide. Implementation of evidence-based […]

MDMA-assisted therapy for moderate to severe PTSD: A randomized, placebo-controlled phase 3 trial

This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy and safety of 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus placebo with identical therapy in participants with moderate to severe post-traumatic stress disorder (PTSD). Changes in Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total severity score (primary endpoint) and Sheehan Disability Scale (SDS) functional impairment score (key secondary […]

Reconnecting to Internal Sensations and Experiences (RISE): An online, multi-session intervention improves interoceptive sensibility for military personnel

Objective This preregistered randomized controlled trial tested the effects of a four-session, online interoceptive awareness intervention relative to an active comparator, matched for time and attention on interoception and suicidal ideation. Method Participants (N = 195; 69% male; mean age = 37) were active duty service members (62%) and veterans (38%) who completed measures of interoceptive sensibility, interoceptive accuracy, […]

Skills to Enhance Positivity in adolescents at risk for suicide: Protocol for a randomized controlled trial

Background Suicide and suicidal behavior during adolescence have been steadily increasing over the past two decades. The preponderance of interventions focuses on crisis intervention, underlying psychiatric disorders, regulating negative affect, and reducing cognitive distortions. However, low positive affectivity may be a mechanism that contributes to adolescent suicidal ideation and behaviors independent of other risk factors. […]

Suicide under the Nazi-regime: A case-control study among Amsterdam Jews

Objective: Jewish suicides increased heavily under Nazi-rule. This research investigated risk factors for dying from suicide according to sociodemographic characteristics, local context, and time periods. Methods: Nazi-registration of Amsterdam residents of Jewish origin in 1941 linked to death and suicide lists. The added suicides after the Nazi-invasion (1940, n = 115) and the suicides when deportation trains […]

Pilot randomized controlled trial of a brief strategy to prevent suicide after discharge from residential addiction treatment

Introduction Veterans are at greater risk for suicide and veterans with substance use disorder (SUD) have an even greater risk. Little research has looked into brief interventions to prevent suicide in this population in residential substance use treatment programs. Method We conducted a pilot, randomized controlled trial of a brief suicide prevention strategy called Veterans Affairs Brief Intervention and Contact Program […]

Prevention of re-attempt suicide through brief contact interventions: A systematic review, meta-analysis, and meta-regression of randomized controlled trials

Brief contact intervention (BCI) is a low-cost intervention to prevent re-attempt suicide. This meta-analysis and meta-regression study aimed to evaluate the effect of BCI on re-attempt prevention following suicide attempts (SAs). We systematically searched using defined keywords in MEDLINE, Embase, and Scopus up to April, 2023. All randomized controlled trials (RCTs) were eligible for inclusion […]

A culturally adapted manual‑assisted problem‑solving intervention (CMAP) for adults with a history of self‑harm: A multi‑centre randomised controlled trial

Background Self-harm is an important predictor of a suicide death. Culturally appropriate strategies for the prevention of self-harm and suicide are needed but the evidence is very limited from low- and middle-income countries (LMICs). This study aims to investigate the effectiveness of a culturally adapted manual-assisted problem-solving intervention (CMAP) for patients presenting after self-harm. Methods […]

Effects of community-based caring contact in reducing thwarted belongingness among postdischarge young adults with self-harm: Randomized controlled trial

Background: For patients with self-harm behaviors, the urge to hurt themselves persists after hospital discharge, leading to costly readmissions and even death. Hence, postdischarge intervention programs that reduce self-harm behavior among patients should be part of a cogent community mental health care policy. Objective: We aimed to determine whether a combination of a self-help mobile […]

Suicide prevention intervention for vulnerable emerging adult sexual minorities: A pilot hybrid effectiveness randomized control trial

Background Suicide attempts and suicide death disproportionately affect sexual and gender minority emerging adults (age 18-24 years). However, suicide prevention strategies tailored for emerging adult sexual and gender minority (EA-SGM) groups are not widely available. The Safety Planning Intervention (SPI) has strong evidence for reducing the risk for suicide in the general population, but it […]

Addressing help-seeking, stigma and risk factors for suicidality in secondary schools: Short-term and mid-term effects of the HEYLiFE Suicide Prevention Program in a randomized controlled trial

Background Suicidal ideation and suicide attempts present a serious public health concern among adolescents and young adults. School-based suicide prevention programs are a key tool for addressing this problem. However, more research is necessary to assess their effectiveness, acceptability, and safety. In response, the HEYLiFE suicide prevention program was developed to enhance help-seeking, reduce stigma […]

Impact of sources of strength on adolescent suicide deaths across three randomized trials

Universal interventions are key to reducing youth suicide rates, yet no universal intervention has demonstrated reduction in suicide mortality through an RCT. This study pooled three cluster-RCTs of Sources of Strength (n=78 high schools), a universal social network-informed intervention. In each trial, matched pairs of schools were assigned to immediate intervention or wait-list. Six schools were assigned […]

Evaluating the efficacy of a community participatory intervention to prevent suicide in Thailand: A randomised controlled trial protocol

Introduction: The age-standardised suicide mortality rate in Thailand has been stable at a high level in recent years, highlighting the need for suicide prevention interventions. In Thailand, community involvement plays a key role in health promotion. The aim of this ongoing trial is to evaluate the efficacy of a community participatory intervention in two subdistricts in […]

Efficacy of a digital mental health intervention embedded in routine care compared with treatment as usual in adolescents and young adults with moderate depressive symptoms: Protocol for randomised controlled trial

Introduction: There are unmet mental health needs of depressed adolescents and young adults (AYAs) across the USA. Behavioural technology adequately integrated into clinical care delivery has potential to improve care access and efficiency. This multisite randomised controlled trial evaluates how a coach-enhanced digital cognitive behavioural intervention (dCBI) enhances usual care for depressed AYAs in paediatric practices […]

A blended face‑to‑face and smartphone intervention to improve suicide prevention literacy and help‑seeking intentions among construction workers: a randomised controlled trial

Purpose: In Australia and elsewhere, suicide rates among construction workers remain high. Construction workplaces are thus an important setting for targeted suicide prevention programs. This study aimed to compare suicide prevention literacy and help-seeking intentions among participants receiving face-to-face suicide prevention training, with those receiving face-to-face training augmented by a smartphone application. Methods: A two-arm randomised controlled […]