Resource Tag: CHOLESTEROL

Background Cholesterol and cholesterol metabolism, involved in continued neural plasticity, has been associated to suicide and suicidal behavior. Apolipoprotein E (ApoE) plays an important role in the cholesterol metabolism. The purpose of this study was to investigate whether ApoE in cerebrospinal fluid was related to severity of suicidal behavior as measured by number of earlier […]

There are inconsistent reports showing that the relationship between total cholesterol (TC) level and suicidality might be gender-specific. We compared 30 first-episode schizophrenia (FES) patients reporting suicidal ideation based on the Operational Criteria for Psychotic Illness (OPCRIT) checklist with 70 FES patients, who have never experienced suicidal ideation. After controlling for potential confounders, higher TC […]

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This review considers the evidence from epidemiological studies on serum cholesterol lowering & psychiatric disturbances. The available evidence does not seem to substantiate the view that large-scale intervention to reduce cholesterol concentrations could lead to more violent & aggressive behaviour, & generally greater unhappiness. In recent trials using statin treatment, there were slightly fewer deaths […]

This article examines the relationship between low serum cholesterol & mood disorders as well as the relationship between cholesterol & suicide ideation, suicide attempts, & parasuicide. (60 refs.)

This article reviews molecular genetic studies in suicidal behaviour & emphasizes findings on new genes. Topics reviewed include: serotonin & suicidal behaviour; genes involved in serotonergic neurotransmission; catecholamines; genes involved in neurotransmission; neurotrophins; & other genes & suicidal behaviour. (167 refs.)

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The authors examined the relationship between cholesterol metabolism & suicidality in carriers of Smith-Lemli-Opitz syndrome & their families. Structured interviews were conducted with 51 carriers of this syndrome & 54 matched comparison subjects. There were significantly more suicide attempters & completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects but family history […]

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Published in “The Suicidal Process: Challenges for Treatment and Prevention”

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In this investigation, the course of serum cholesterol concentrations was measured in depressed patients during treatment. Degrees of depression & suicidality were measured with the Hamilton Depression Rating Scale. Although there was a significant reduction in depression & suicidality scores, neither a significant changed in serum cholesterol levels nor a correlation between cholesterol levels & […]

The aim of the current study was to determine which variable would be a better predictor of suicide risk: perceived social support or serum cholesterol level. Perceived social support was found to be a better predictor for African Americans. Depressed patients with a history of suicide attempt had a significantly lower serum cholesterol level, scored […]

For the original article by D Lester, please see SIEC #2003-1311

In order to study the association between serum total cholesterol, depression & suicide, a total of 29,133 men aged 50-69 years were followed up for 5-8 years. Serum protein & high-density lipoprotein cholesterol concentrations were analysed, as were levels of depression, treatment for depression, & deaths from suicide. The researchers found that low serum total […]

The aim of this study was to examine whether (i) major depression is accompanied by lower serum HDL-C or by abnormal levels of total cholesterol, triglycerides, low-density lipoprotein-C or vitamin E; (ii) suicidal attempts are related to lower serum HDL-C and (iii) there are significant associations between serum HDL-C and immune/inflammatory markers. It was found […]

For the original article by J Brunner et al., please see SIEC #2002-0500

This study compared the serum cholesterol levels of Irish psychiatric inpatients with & without recent suicidal behavior. The characteristic of novelty seeking was analyzed as an intermediary variable. Of the 155 inpatients included, 34 had recently attempted suicide. Significantly lower average cholesterol levels were found in women who had attempted suicide before hospitalization than for […]