Cholesterol and cholesterol metabolism, involved in continued neural plasticity, has been associated to suicide and suicidal behavior. Apolipoprotein E (ApoE) plays an important role in the cholesterol metabolism. The purpose of this study was to investigate whether ApoE in cerebrospinal fluid was related to severity of suicidal behavior as measured by number of[…]
Higher total cholesterol level is associated with suicidal ideation in first-episode schizophrenia females.
There are inconsistent reports showing that the relationship between total cholesterol (TC) level and suicidality might be gender-specific. We compared 30 first-episode schizophrenia (FES) patients reporting suicidal ideation based on the Operational Criteria for Psychotic Illness (OPCRIT) checklist with 70 FES patients, who have never experienced suicidal ideation. After controlling for potential confounders, higher TC[…]
Association between serum cholesterol and depression, aggression and suicidal ideation in war veterans with posttraumatic stress disorder: A cross-sectional study.
The Association of low Serum Cholesterol With Depression and Suicidal Behaviours: new Hypotheses for the Missing Link
This review considers the evidence from epidemiological studies on serum cholesterol lowering & psychiatric disturbances. The available evidence does not seem to substantiate the view that large-scale intervention to reduce cholesterol concentrations could lead to more violent & aggressive behaviour, & generally greater unhappiness. In recent trials using statin treatment, there were slightly fewer deaths[…]
This article examines the relationship between low serum cholesterol & mood disorders as well as the relationship between cholesterol & suicide ideation, suicide attempts, & parasuicide. (60 refs.)
This article reviews molecular genetic studies in suicidal behaviour & emphasizes findings on new genes. Topics reviewed include: serotonin & suicidal behaviour; genes involved in serotonergic neurotransmission; catecholamines; genes involved in neurotransmission; neurotrophins; & other genes & suicidal behaviour. (167 refs.)
The authors examined the relationship between cholesterol metabolism & suicidality in carriers of Smith-Lemli-Opitz syndrome & their families. Structured interviews were conducted with 51 carriers of this syndrome & 54 matched comparison subjects. There were significantly more suicide attempters & completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects but family history[…]