Mood disorders and aggressive traits mediate effects of reported childhood adversity on suicide attempt risk

Background Childhood adversity (CA) is linked to suicidal behavior as well as to mood disorders and aggressive traits. This raises the possibility that depression and aggressive traits mediate the relationship of childhood adversity to suicide risk. Moreover, it is not known if they operate independently or interactively. Aims To determine whether, and how, mood disorders […]

A 5-year suicide rate of adolescents who enrolled to an open dialogue-based services: A nationwide longitudinal register-based comparison

In the Open Dialogue (OD) based psychiatric services adolescent patients receive less medication and are more often treated within an outpatient setting as compared to standard services. An evaluation of the possible risks of implementing OD are required. The aim of this longitudinal register-based study was to evaluate how treatment under OD is associated with […]

A systematic review exploring characteristics of youth with severe and enduring mental health problems (SEMHP)

A small group of youth and emerging adults deals with severe and enduring mental health problems (SEMHP). Current mental health care struggles to recognize and treat this group timely and adequately, leaving these youth between the cracks of the system. A first step to improve care for this group is to gain a deeper understanding […]

Prevalence and correlates of suicidal ideation and deliberate self-harm in Canadian adolescents during the coronavirus disease 2019 pandemic

Objective In light of recent evidence that the coronavirus disease 2019 (COVID-19) pandemic has resulted in marked increases in depression, anxiety, substance use, and other mental health concerns among Canadian adolescents, we investigated the rates of self-harm thoughts and behaviours in this population. Specifically, this study explored: (1) the demographic and geographic distributions of suicidal […]

A suicide prevention strategy for youth presenting to the emergency department with suicide related behaviour: Protocol for a randomized controlled trial

Background Suicide is a leading cause of death among adolescents in North America. Youth who present to the Emergency Department (ED) with acute suicidality are at increased risk for eventual death by suicide, thereby presenting an opportunity for secondary prevention of suicide. The current study evaluates the effectiveness of a standardized individual and family-based suicidal […]

Increased readmission rates in younger male patients due to suicidal risk in newly diagnosed depressive disorders after initiation of serotonin reuptake inhibitors

Background Depressive disorders have a prevalence of 322 million people worldwide and are a leading cause of morbidity. These disorders can affect individuals of all ages and can present over time. Due to the diversity in the  presentation of depressive disorders, vigilance towards depressive disorders can lead to more timely and effective treatment. Serotonin Selective […]

Genetic risk, parental history, and suicide attempts in a diverse sample of US adolescents

Background: Adolescent suicide is a major health problem in the US marked by a recent increase in risk of suicidal behavior among Black/African American youth. While genetic factors partly account for familial transmission of suicidal behavior, it is not clear whether polygenic risk scores of suicide attempt can contribute to suicide risk classification. Objectives: To evaluate the […]

Mood disorders and aggressive traits mediate effects of reported childhood adversity on suicide attempt risk

Background: Childhood adversity (CA) is linked to suicidal behavior as well as to mood disorders and aggressive traits. This raises the possibility that depression and aggressive traits mediate the relationship of childhood adversity to suicide risk. Moreover, it is not known if they operate independently or interactively. Aims: To determine whether, and how, mood disorders and aggressive […]